中国媒介生物学及控制杂志 ›› 2011, Vol. 22 ›› Issue (1): 35-37.

• 论著 • 上一篇    下一篇

雷州市黄胸鼠对杀鼠灵的抗药性调查

高志祥, 邱俊荣, 冯志勇, 姚丹丹, 隋晶晶, 曾繁娟   

  1. 广东省农业科学院植物保护研究所,广州 510640
  • 收稿日期:2010-05-11 出版日期:2011-02-20 发布日期:2011-02-20
  • 通讯作者: 冯志勇, Email: fengzy@tom.com
  • 作者简介:高志祥(1982-),男,硕士,助理研究员,主要从事鼠类行为生理生态和鼠害可持续控制技术研究。
  • 基金资助:

    广东省自然科学基金(8151064001000001); 广东省突发公共事件应急技术研究中心项目(2008B080701044); 广东省科技计划项目(2009A030302008)

Resistance of Rattus tanezumi to warfarin in Leizhou city

GAO Zhi-xiang, QIU Jun-rong, FENG Zhi-yong, YAO Dan-dan, SUI Jing-jing, ZENG Fan-juan   

  1. Institute of Plant Protection of Guangdong Province, Guangzhou 510640, Guangdong Province, China
  • Received:2010-05-11 Online:2011-02-20 Published:2011-02-20
  • Supported by:

    Supported by the Natural Science Foundation of Guangdong (No. 8151064001000001), Research Center of Public Health Emergency Response of Guangdong (No. 2008B080701044) and Scinece and Technological Project of Guangdong (No. 2009A030302008)

摘要:

目的 检测捕自广东省雷州市的黄胸鼠在应用第二代抗凝血灭鼠剂数年后对第一代药物的抗性发生水平。方法 将捕自雷州市郊的黄胸鼠室内预饲一段时间后,选择合格试鼠,配制0.005%杀鼠灵毒饵采用无选择性摄食试验法饲毒(LFP法),观察并分析试鼠的死亡率与食毒量的关系。结果 黄胸鼠抗性检测合格试鼠共36只,检测结束后试鼠因药物死亡32只,试鼠对杀鼠灵的抗性发生率为11.11%,接近抗性种群形成临界水平;死亡试鼠性别间在致死剂量和死亡时间上差异无统计学意义(df=30,Pd=0.987,Pt=0.971);全部死亡试鼠平均食毒剂量(115.71±53.84)mg/kg,平均死亡时间(7.2±2.4)d。结论 在抗凝血灭鼠剂的使用过程中要定期监测害鼠对药物的敏感度变化趋势,为药物灭鼠的选择提供依据,以节省有限的药物资源。

关键词: 黄胸鼠, 杀鼠灵, 抗药性

Abstract:

Objective To measure the resistance of Rattus tanezumi to the 1st generation agent after their exposure to the 2nd generation anticoagulant rodenticides for several years in Leizhou city, Guangdong province. Methods Rats captured in Leizhou suburb were raised indoor for days. Eligible rodents were subject to non-selective feeding test using 0.005% warfarin baits. The relationship between the mortality and intakes was recorded and analyzed. Results Among 36 eligible rodents, 32 died from the consumption of agents. The development of warfarin resistance in the subjects, 11.11%, was close to the critical level of development of population resistance. There was no significant difference in the lethal dose and lethal time between male and female rats (df=30, Pd=0.987, Pt=0.971). The average volume of toxicant intake was (115.71±53.84) mg/kg for dead rats, with the average lethal time of (7.2±2.4) d. Conclusion The changing trends of rodent sensitivity to anticoagulant rodenticides should be regularly monitored during the application of these agents for economically optimizing the use of drugs.

Key words: Rattus tanezumi, Warfarin, Insecticide resistance

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