中国媒介生物学及控制杂志

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溴氰菊酯对白纹伊蚊C6/36细胞增殖的抑制作用及抑制后细胞的恢复

芦晓黎; 赵彤言; 薛瑞德; 陆宝麟   

  1. 军事医学科学院微生物流行病研究所 北京100071
  • 出版日期:1998-02-20 发布日期:1998-02-20

Inhibitory Effects of Deltamethrin(DM) on the Proliferation ofAedes albopictus C6/36 Cell Line and Regeneration of Inhibitied Cells

Lu Xiao-li; Zhao Tong-yuan; Xue Rui-de; Lu Bao-lin   

  1. Institute of Microbiology and Epidemiology ,Academy of Military Medical Sciences, Beijing 100071
  • Online:1998-02-20 Published:1998-02-20

摘要: 目的:多侧面深入了解溴氰菊酯的毒性作用机制。方法:采用冲击式测试法(即药物与细胞接触时间有限,24小时),动态观察溴氰菊酯(浓度在40μg/ml以下)对C6/36细胞增殖的影响。结果:低浓度溴氰菊酯(10μg/ml)对C6/36细胞增殖没有影响,较高浓度溴氰菊酯(20μg/ml、40μg/ml)则对C6/36细胞增殖有明显抑制作用,抑制作用强度随药物浓度的增加而增加,去除药物作用后,受抑制的细胞又重新恢复生长、分裂。结论:这种抑制作用是可逆的。

关键词: 溴氰菊酯, 白纹伊蚊C6/36细胞株, 增殖, 抑制作用

Abstract: In this paper,the C6/36 cell growth rate and karyokinesis, after adding the DM(10μg/ml、20μg/ml、40μg/ml) on culture, were dynamic observed using ictus method for revealing the effects of DM on C6/36 cell line proliferation.The inhibitory effects of higher DM on the cell line proliferation and a doseresponse effects were observed.The inhibited cells were regenerated after recession of DM treatment on the cell line.It was showed inhibitory effects of DM on the proliferation of C6/36 cell was reversible.