关键词: 恙虫病, 传播宿主, 动物实验

Abstract: Objective:To study infection state of Richettsia tsutsugamushi(Rt) among mouse host in epidemic focus in Hebei province.Methods:Following items were carried out:to catch mice in epidemic village and field(catch-mouse),observe abnormal phenomena of liver and spleen,inoculate liver and spleen samples to small white mouse with Kunming species(experimental mouse),smear and/or freeze cut section of liver and spleen from experimental mouse to detect Rt,take blood specimens from catch-mouse and experimental mouse to test antibodies against Rt with IFA.Results:In the different species mice caught,the rate of hepatomegaly and/or splenomegaly were from 60% to 100%,and prevalance of Rt antibody were from 0% to 50%.In the experimental mouse with inoculation liver and spleen samples came from different species mice caught,incidence of the disease were from 96.23% to 100%,smear positive rate of Rt were 25% to 50%,9 of 10 freezing cut section samples were Rt positive,the positive rate of Rt antibodies of experimental mouse sera came from Rattus norvegicusit was 9.52%.Conclusion:Transmissible hosts in the residence area are Rattus norvegicusit,and in the field are Cricetulus triton and Apodemus agrarius.