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### 安徽省肾综合征出血热Ⅰ型灭活疫苗的安全性、免疫性评价及其流行病学效果考核

1. 1.安徽省卫生防疫站 合肥 230061;2.霍邱县卫生防疫站;3.颖上县卫生防疫站;4.六安市卫生防疫站
• 出版日期:1996-08-20 发布日期:1996-08-20

### Evaluation of Safty, Immunity and Epidemiological Effects of Inactivated HFRS Vaccine Ⅰ Cultured in M. unguiculatus Kidney Cell

Luo Zhao-zhuang;Liu Hong;Wang Yi-yin et al

• Online:1996-08-20 Published:1996-08-20

Abstract: An investigation on HFRS foci pattern was conducted in Anhui province by means of epidemiology, serology and etiology. It showed that the province mainly belonged to wild rodent epidemic area(type Ⅰ), on which inactivated HFRS vaccine Ⅰ cultured in M. unguilatus kidney cell was selected in the study.The research was taken up in the epidemic area of up Huai River of the province, according to several surveillance of population prevalence and rodent's infection of HFRS viruses. The sample size was calculated on HFRS incidence rate and protection rate of the vaccine. More than 20, 000 persons were selected as trial population and randomly divided into inoculation and control groups who were parallel by statistic test(P>0. 05). The vaccine had good antigen during one year's observation. The rate of the vaccine-induced antibody was 95. 15 %( 59/62 ) after third injection(GMT=32.38). IFA antibody existed 3 to 6 months, and the positive rate of the inoculation group was more than 90 % on 360th day after third injection. The positive rate of neutralization was 54. 17 %(13/24) by MCPENT, GMT was 16. 16. There was no severe innormal reaction in 10793 recipients of inoculation program, the reaction rate was below 1 %. The vaccine was safe and had good immuno response. During one year's observation there was no HFRS case in run-in group and the incidence rate of the controls was 123.87/100,000,the protection rate was 100 %. The result showed the epidemiological effect was satisfied in short period.