中国媒介生物学及控制杂志 ›› 2019, Vol. 30 ›› Issue (4): 371-373.DOI: 10.11853/j.issn.1003.8280.2019.04.003

• 虫媒传染病专题报道 • 上一篇    下一篇

登革热暴发9年后感染者抗体阳性率调查

骆淑英1, 刘营2, 傅涛1, 孙继民2   

  1. 1义乌市疾病预防控制中心免疫规划科, 浙江 义乌 322000;
    2 浙江省疾病预防控制中心, 浙江 杭州 310051
  • 收稿日期:2019-03-01 出版日期:2019-08-20 发布日期:2019-08-20
  • 通讯作者: 孙继民,Email:jmsun@cdc.zj.cn
  • 作者简介:骆淑英,女,主任医师,主要从事传染病预防控制工作,Email:1628865370@qq.com
  • 基金资助:
    国家自然科学基金(81872675);浙江省卫生健康委员会科研项目(2017KY291,2018KY338)

An investigation of seroprevalence of IgG antibodies in infected cases nine years after a dengue outbreak

LUO Shu-ying1, LIU Ying2, FU Tao1, SUN Ji-min2   

  1. 1 Yiwu Center for Disease Control and Prevention, Yiwu 322000, Zhejiang Province, China;
    2 Zhejiang Center for Disease Control and Prevention
  • Received:2019-03-01 Online:2019-08-20 Published:2019-08-20
  • Supported by:
    Supported by the National Natural Science Funds of China (No. 81872675) and Medical Research Program of Zhejiang Province (No. 2017KY291, 2018KY338)

摘要: 目的 了解登革热病例感染登革热病毒(DENV)9年后IgG抗体阳性情况及影响因素,为登革热预防控制提供科学依据。方法 以2009年浙江省义乌市一起登革热(DENV-3)暴发疫情中的感染者为调查对象,于2018年5-8月采集登革热既往感染者血清,采用ELISA法检测DENV IgG抗体,计算样本中DENV IgG抗体分布情况,并分析IgG抗体阳性的相关因素。结果 共采集登革热既往感染者血清标本126份,DENV IgG抗体阳性率平均为79.37%(100/126);男性和女性感染者中DENV IgG抗体阳性率分别为75.00%(30/40)和81.40%(70/86),差异无统计学意义(χ2=0.682,P=0.409);1~、21~、41~和≥61岁年龄组血清登革热IgG抗体阳性率分别为100%、94.12%、85.42%和67.86%,差异有统计学意义(χ2=9.161,P=0.027);病例和隐性感染者DENV IgG抗体阳性率分别为89.11%和40.00%,差异有统计学意义(χ2=29.511,P=0.000)。结论 DENV感染9年后感染者体内DENV IgG抗体仍广泛存在,且病例的阳性率明显高于隐性感染者。

关键词: 登革热, 血清阳性率, 抗体

Abstract: Objective To investigate the seroprevalence of immunoglobulin G (IgG) antibodies in dengue cases nine years after being infected with dengue virus and associated factors, and to provide a scientific basis for dengue prevention and control. Methods A seroprevalence survey was conducted on dengue cases from a dengue outbreak (dengue virus-3) in Yiwu, Zhejiang province, China, 2009. Serum samples were collected from them from May to August, 2018 for dengue virus IgG antibody detection by ELISA. The distribution of dengue virus IgG antibodies in the serum samples was calculated, and associated factors for positive dengue virus IgG antibodies were analyzed. Results A total of 126 serum samples from dengue cases were collected and the mean seroprevalence of dengue virus IgG antibodies was 79.37% (100/126). The seroprevalence of males and females was 75.00% (30/40) and 81.40% (70/86), respectively, showing no significant difference (χ2=0.682, P=0.409). The seroprevalence in the groups aged 1-, 21-, 41-, and ≥ 61 years were 100%, 94.12%, 85.42%, and 67.86%, respectively; there was a significant difference in the seroprevalence of dengue virus IgG antibodies between the four groups (χ2=9.161, P=0.027). The seroprevalence of dengue virus IgG antibodies in apparent infection cases was significantly higher than that in inapparent infection cases (89.11% vs 40.00%, χ2=29.511, P=0.000). Conclusion Dengue virus IgG antibodies are detectable in dengue cases nine years after infection. The seroprevalence of dengue virus IgG antibodies in apparent cases is significantly higher than that in inapparent cases.

Key words: Dengue, Seroprevalence, Antibody

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