Chines Journal of Vector Biology and Control ›› 2017, Vol. 28 ›› Issue (4): 354-358.DOI: 10.11853/j.issn.1003.8280.2017.04.012

Previous Articles     Next Articles

The molecular characteristics and epidemiological analysis of Hantavirus in southeast coastal area of China from 1980 to 2015

HUANG Peng1, YANG Zhang-nyu2, LIU Yuan3, YAO Ping-ping2, HU Jian-li4, WANG Xiao-chen4, YU Jian-jia5, LI Jun3, HAN Ya-ping3, JIN Ke3, YANG Long6, ZHANG Yun6, YUE Ming3   

  1. 1 Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu Province, China;
    2 Zhejiang Center for Disease Control and Prevention;
    3 The First Affiliated Hospital of Nanjing Medical University;
    4 Jiangsu Center for Disease Control and Prevention;
    5 Danyang People's Hospital;
    6 Huadong Research Institute for Medicine and Biotechnics
  • Received:2017-04-06 Online:2017-08-20 Published:2017-08-20
  • Supported by:
    Supported by the National Natural Science Foundation of China (No. 81473036)

东南沿海地区1980-2015年汉坦病毒分子特征及流行病学分析

黄鹏1, 杨章女2, 刘源3, 姚苹苹2, 胡建利4, 王笑辰4, 俞建家5, 李军3, 韩亚萍3, 金柯3, 杨龙6, 张云6, 岳明3   

  1. 1 南京医科大学公共卫生学院流行病与卫生统计学系, 南京 211166;
    2 浙江省疾病预防控制中心, 浙江省传染病疫苗与预防控制研究重点实验室, 杭州 310051;
    3 南京医科大学第一附属医院, 南京 210029;
    4 江苏省疾病预防控制中心, 南京 210009;
    5 江苏省丹阳市人民医院, 江苏 丹阳 212300;
    6 中国人民解放军南京军区军事医学研究所, 江苏 南京 210002
  • 通讯作者: 岳明,Email:njym08@163.com
  • 作者简介:黄鹏,男,博士,讲师,主要从事传染病流行病学研究,Email:hp19880310@163.com
  • 基金资助:
    国家自然科学基金(81473036)

Abstract: Objective To analyze the genetic evolution and epidemiological pattern of Hantavirus (HV) isolated from different hosts, vectors and patients in different time from different regions of southeastern China from 1980 to 2015. Methods The mutation site and frequency in S, M segment hypervariable region of HV isolated from southeastern China,including Jiangsu province, Zhejiang province, Shanghai and Fujian province, from 1980 to 2015 were detected. Combining the information of HV, hosts, vectors, environment and epidemiology, the HV evolution laws in different regions, time, natural reservoir and important vectors were analyzed. Results The HV strains isolated from the hemorrhagic fever with renal syndrome (HFRS) patients in the southeast coastal area were mainly the Hantaan virus (HTNV), which were highly homologous with the 76-118 strain. While the Seoul virus (SEOV) carried by patients exhibited the highest sequence similarity to the Z37 strain. The southeast coastal area is the mixed type of HV-affected area, with apparent endemicity. The HV isolated from the rodents shared the highest identity to SEOV. The HV clades were related to host types and the locations of sample collection. SEOV was carried primarily by Rattus norvegicus, while HTNV was carried primarily by Apodemus agrarius. Conclusion The formation and maintenance of HFRS epidemic areas show a certain regularity.

Key words: Hantavirus, Host, Genetic evolution, Epidemiological regularity

摘要: 目的 探讨1980-2015年从东南沿海地区不同地域、时间、宿主、媒介及患者中分离的汉坦病毒(HV)的遗传进化及流行规律。方法 运用遗传流行病学、分子流行病学和生物信息学方法分析1980-2015年东南沿海地区(江苏、浙江、福建省和上海市)HV的S、M片段高变区基因的变异位点与频率,结合HV、宿主、媒介与生态环境4个方面及流行病学资料,分析HV在不同地域、时间、自然宿主以及重要传播媒介之间的演变规律。结果 东南沿海地区肾综合征出血热(HFRS)临床患者感染的病毒以汉滩型(HTN)HV居多,主要与76-118株同源为主,汉城型病毒(SEOV)与Z37株相似的病毒为主;为HV HTN和SEO的混合型疫区,呈现高度的地理聚集现象;鼠类携带HV以SEOV为主,病毒分支与携带宿主的种类和采集地点有关,SEOV主要来源于褐家鼠,HTNV主要来源于黑线姬鼠。结论 HV和HFRS疫区的形成和维持具有一定的内在规律。

关键词: 汉坦病毒, 宿主, 遗传进化, 流行规律

CLC Number: