杭州市2020－2022年入境人员检疫管理措施对登革热疫情的影响分析

王哲, 黄仁杰, 朱雷, 金彬彬, 韦凌娅, 孙昼, 孔庆鑫

doi:10.11853/j.issn.1003.8280.2024.01.016

中国媒介生物学及控制杂志 >

2024 , Vol. 35 >Issue 1: 89 - 94

DOI: https://doi.org/10.11853/j.issn.1003.8280.2024.01.016

调查研究

杭州市2020－2022年入境人员检疫管理措施对登革热疫情的影响分析

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杭州市疾病预防控制中心传染病防制所, 浙江杭州 310021

王哲，男，硕士，主管医师，主要从事传染病防控工作，E-mail：mrwangzhe@oulook.com

收稿日期: 2023-08-11

网络出版日期: 2024-03-05

基金资助

杭州市卫生科技计划（A20220843）；杭州市农业与社会发展科研引导项目（20220919Y058）；杭州市医学重点学科项目

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Analysis of the impact of quarantine management measures for inbound passengers on dengue fever in Hangzhou， Zhejiang Province， China， from 2020 to 2022

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Institute of Infectious Disease Control and Prevention, Hangzhou Center for Disease Control and Prevention, Hangzhou, Zhejiang 310021, China

Received date: 2023-08-11

Online published: 2024-03-05

Supported by

General Projects of Medical and Health Science and Technology Plan of Hangzhou (No. A20220843); Scientific Research Guidance Program for Agricultural and Social Development of Hangzhou (No. 20220919Y058); Hangzhou Medical Key Discipline Project

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摘要

目的了解杭州市新型冠状病毒感染疫情防控期间针对入境人员的检疫管理措施对登革热疫情的影响。方法收集杭州市2017年1月1日－2022年12月31日登革热病例信息，2017－2022年蚊媒监测数据和杭州市入境人数，使用Excel 2019软件汇总数据，使用R 4.2.0软件进行统计分析。检疫管理措施实施前后流行特征比较采用χ²检验，蚊媒密度监测数据比较采用重复测量的方差分析，入境人数与登革热病例相关性分析采用Spearman秩相关。结果 2020年3月26日－2022年12月31日入境人员检疫管理措施实施后，杭州市累计报告登革热输入病例5例，输入传播风险强度为0，明显低于实施前（250例，4.82）；检疫管理措施实施后，登革热输入病例的人群特点、输入季节和输入地区分布特征与实施前差异均无统计学意义（均P>0.05）。检疫管理措施实施后，输入病例中分别有4和1例在隔离点和口岸发现，实施前则以医院发现为主（246/250，98.40%）；发病至诊断时间间隔显著短于实施前（t=2.053，P=0.041）。2017－2019年伊蚊幼蚊布雷图指数月平均值和成蚊帐诱指数月平均值与2020－2022年差异均无统计学意义（均P>0.05）。2017－2022年入境人数与登革热输入病例年报告数存在正相关（r=1.000，P=0.003）。结论杭州市在实施入境人员检疫管理措施后，登革热输入病例显著减少，但在解除入境人员管理后，仍存在登革热传播的风险。

关键词： 登革热; 输入病例; 检疫管理措施; 媒介密度; 本地传播风险

本文引用格式

王哲, 黄仁杰, 朱雷, 金彬彬, 韦凌娅, 孙昼, 孔庆鑫 . 杭州市2020－2022年入境人员检疫管理措施对登革热疫情的影响分析[J]. 中国媒介生物学及控制杂志, 2024 , 35(1) : 89 -94 . DOI: 10.11853/j.issn.1003.8280.2024.01.016

Abstract

Objective To investigate the impact of quarantine management measures for inbound passengers on dengue fever during the prevention and control of novel coronavirus infection in Hangzhou, China. Methods The information on dengue fever cases from January 1, 2017 to December 31, 2022 and the mosquito surveillance data and the number of inbound passengers from 2017 to 2022 in Hangzhou were collected. Excel 2019 software was used to aggregate the data, and R 4.2.0 software was used for statistical analysis. The epidemiological characteristics of dengue fever before and after the implementation of quarantine management measures were compared using the Chi-squared test. The mosquito density surveillance data were compared using repeated-measures analysis of variance. The correlation between the number of inbound passengers and dengue fever cases was investigated using Spearman rank correlation analysis. Results After the implementation of quarantine management measures for inbound passengers from March 26, 2020 to December 31, 2022, a total of 5 imported cases of dengue fever were reported in Hangzhou, and the intensity of the risk of imported transmission was 0, which were significantly lower than those (250 cases, with 4.82 of risk intensity) before the implementation. There were no significant differences in the population characteristics, the season of importation, and the distribution of the source areas of imported dengue fever cases before and after the implementation of quarantine management measures (all P>0.05). After the implementation of quarantine management measures, four imported cases were found at isolation sites and one at a port, while 98.40% (246/250) of cases were found in hospitals before the implementation of quarantine management measures. The time interval between disease onset and diagnosis was significantly shorter than before the implementation of quarantine management measures (t=2.053, P=0.041). The mean monthly Breteau index and mean monthly net trap index of Aedes mosquitoes during 2017 to 2019 were not significantly different from those during 2020 to 2022 (all P>0.05). The annual number of inbound passengers was positively correlated with the annual numbers of imported cases of dengue fever from 2017 to 2022 (r=1.000, P=0.003). Conclusions The number of imported cases of dengue fever has decreased significantly after the implementation of quarantine management measures for inbound passengers in Hangzhou. However, there is still a risk of outbreak after lifting the management of inbound passengers.

Key words： Dengue fever; Imported case; Quarantine management measure; Vector density; Risk of local transmission

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