Objective To analyze epidemiological characteristics and outbreak of dengue fever in Yunnan Province, China, so as to provide a scientific basis for formulating effective prevention and control measures. Methods Relevant data on dengue fever cases and outbreaks reported in Yunnan Province during 2013-2022 were collected from the “Infectious Disease Surveillance System” and “Public Health Emergency Management Information System” of “China Disease Control and Prevention Information System”. The concentration method was used to analyze seasonal characteristics. Excel 2007 software was used to sort out the data. MapInfo 7.8 software was used to draw the map. SPSS 26.0 was used to analyze the correlation, and the Chi-square test was used to compare the rate or composition ratio. The descriptive epidemiological method was used to analyze the epidemiological characteristics and outbreak response to dengue fever. Results A total of 16 774 cases of dengue fever were reported in Yunnan Province from 2013 to 2022, including 11 944 local cases, 4 521 overseas imported cases, and 309 domestic imported cases, with an average annual reported incidence of 3.53/100 000. The disease showed a high incidence every other year. The concentration (M) was 0.84, showing strong seasonality. Imported cases mainly occurred from June to October, and local cases mostly from August to November. The male-to-female ratio of imported cases was slightly higher than that of local cases (χ2=37.596, P<0.001). The majority of local cases were 30～<40 years old (20.14%), and the majority of imported cases were 20～<30 years old (27.58%). The local cases were found in 5 border prefectures (cities). The overseas imported cases were mainly from southeast Asian countries and African countries, and Myanmar, Cambodia, and Laos were the main source countries (96.81%). The domestic imported cases were mainly from Xishuangbanna Dai Autonomous Prefecture (85.76%). The majority of cases were farmers, commercial service personnel, cadres/retirees, housekeepers, job-waiting people, and students. Commercial service personnel accounted for the highest proportion in local cases (21.89%), while farmers accounted for the highest proportion in imported cases (39.90%). There was a significant difference in occupational distribution between imported cases and local cases (χ2=1 535.415, P<0.001). A total of 28 dengue fever outbreaks were reported from 2013 to 2022, including 1 major event and 27 general events. The number of reported cases accounted for 83.41% of the total number of cases, and each event involved an average of 499.71 cases. The median time from the onset of the first case to the verification of event occurrence was 7 (5, 9) days, and the median duration of the outbreak was 110 (27, 140) days. Twenty-five outbreaks occurred in villages/communities. Conclusions Dengue fever in Yunnan has obvious seasonal, aggregated, and regional distribution patterns. We need to further strengthen imported case management, disease vector surveillance and control, and the prevention and control of dengue fever in key areas.
[1] 龚甫哲. 2018年9月世界卫生组织关于登革热疫苗的意见书[J]. 疾病监测,2019,34(3):278-284. DOI:10.3784/j.issn. 1003-9961.2019.03.020.Gong FZ. Dengue vaccine:WHO position paper-September 2018[J]. Dis Surveill,2019,34(3):278-284. DOI:10.3784/j.issn. 1003-9961.2019.03.020.(in Chinese)
[2] World Health Organization. Global strategy for dengue prevention and control,2012-2020[R]. Geneva:World Health Organization,2012.
[3] 自登云,陈伯权,俞永新. 虫媒病毒与虫媒病毒病[M]. 昆明:云南科技出版社,1995:164-177.Zi DY,Chen BQ,Yu YX. Arbovirus and arbovirus disease[M]. Kunming:Yunnan Science and Technology Press,1995:164-177. (in Chinese)
[4] 孟凤霞,王义冠,冯磊,等. 我国登革热疫情防控与媒介伊蚊的综合治理[J]. 中国媒介生物学及控制杂志,2015,26(1):4-10. DOI:10.11853/j.issn.1003.4692.2015.01.002.Meng FX,Wang YG,Feng L,et al. Review on dengue prevention and control and integrated mosquito management in China[J]. Chin J Vector Biol Control,2015,26(1):4-10. DOI:10.11853/j.issn.1003.4692.2015.01.002.(in Chinese)
[5] Yue YJ,Liu XB,Xu M,et al. Epidemiological dynamics of dengue fever in mainland China,2014-2018[J]. Int J Infect Dis,2019,86:82-93. DOI:10.1016/j.ijid.2019.06.015.
[6] 岳玉娟,刘小波,郭玉红,等. 2020-2022年中国登革热时空分布及相关环境因素分析[J]. 环境卫生学杂志,2023,13(5):341-345. DOI:10.13421/j.cnki.hjwsxzz.2023.05.006.Yue YJ,Liu XB,Guo YH,et al. Spatio-temporal distribution and environmental factors of dengue fever in China,2020-2022[J]. J Environ Hyg,2023,13(5):341-345. DOI:10.13421/j.cnki.hjwsxzz.2023.05.006.(in Chinese)
[7] 张海林. 云南省登革热和基孔肯雅热跨境传播、本地流行、发展趋势及对策[J]. 中国媒介生物学及控制杂志,2021,32(1):12-20. DOI:10.11853/j.issn.1003.8280.2021.01.002.Zhang HL. Cross-border spread,indigenous transmission,development trend,and control strategy for dengue fever and chikungunya fever in Yunnan province,China[J]. Chin J Vector Biol Control,2021,32(1):12-20. DOI:10.11853/j.issn.1003. 8280.2021.01.002.(in Chinese)
[8] 刘永华,尹小雄,张海林,等. 云南省德宏州2013-2019年登革热流行特征及媒介伊蚊监测分析[J]. 中国媒介生物学及控制杂志,2021,32(2):173-180. DOI:10.11853/j.issn.1003. 8280.2021.02.011.Liu YH,Yin XX,Zhang HL,et al. Epidemiological characteristics of dengue fever and monitoring of Aedes vector mosquitoes in Dehong Dai and Jingpo Autonomous Prefecture of Yunnan province,China,2013-2019[J]. Chin J Vector Biol Control,2021,32(2):173-180. DOI:10.11853/j.issn.1003. 8280.2021.02.011.(in Chinese)
[9] 中华人民共和国卫生部. WS 216-2008登革热诊断标准[S]. 北京:中国标准出版社,2008.Ministry of Health of the People's Republic of China. WS 216-2008 Diagnostic criteria and principle of management of dengue fever[S]. Beijing:Standards Press of China,2008. (in Chinese)
[10] 国家卫生和计划生育委员会. WS 216-2018登革热诊断标准[S]. 北京:中国标准出版社,2018.National Health and Family Planning Commission of the People's Republic of China. WS 216-2018 Diagnosis for dengue fever[S]. Beijing:Standards Press of China,2018. (in Chinese)
[11] 刘起勇. 我国登革热流行新趋势、防控挑战及策略分析[J]. 中国媒介生物学及控制杂志,2020,31(1):1-6. DOI:10.11853/j.jssn.1003.8280.2020.01.001.Liu QY. Dengue fever in China:New epidemical trend,challenges and strategies for prevention and control[J]. Chin J Vector Biol Control,2020,31(1):1-6. DOI:10.11853/j.jssn. 1003.8280.2020.01.001.(in Chinese)
[12] 李炳辉,朱海龙,马小芳,等. 基于集中度和圆形分布法分析山东省青岛市2017-2020年媒介蚊虫季节性特征[J]. 中国媒介生物学及控制杂志,2022,33(2):230-233,238. DOI:10.11853/j.issn.1003.8280.2022.02.012.Li BH,Zhu HL,Ma XF,et al. Analysis of seasonal characteristics of mosquito vectors in Qingdao city of Shandong province during 2017 and 2020 by the concentration and circular distribution method[J]. Chin J Vector Biol Control,2022,33(2):230-233,238. DOI:10.11853/j.issn.1003.8280.2022.02.012.(in Chinese)
[13] 中国卫生部国际合作司,云南省卫生厅,云南省寄生虫病防治所. 云南边境登革热防治手册[M]. 昆明:云南科技出版社,2011:1-35.International Cooperation Department of the Ministry of Health of China,Yunnan Provincial Department of Health,Yunnan Provincial Institute for Parasitic Disease Prevention and Control. Mannual for dengue fever control in Yunnan border areas[M]. Kunming:Yunnan Science and Technology Press,2011:1-35. (in Chinese)
[14] Hu TS,Zhang HL,Feng Y,et al. Epidemiological and molecular characteristics of emergent dengue virus in Yunnan province near the China-Myanmar-Laos border,2013-2015[J]. BMC Infect Dis,2017,17(1):331. DOI:10.1186/s12879-017-2401-1.
[15] 冯云,张海林,潘虹,等. 云南省登革病毒血清型和基因型多样性及溯源研究[J]. 中华实验和临床病毒学杂志,2017,31(1):24-30. DOI:10.3760/cma.j.issn.1003-9279.2017.01.005.Feng Y,Zhang HL,Pan H,et al. Diversity of serotypes and genotypes and molecular tracing of Dengue viruses isolated from dengue fever cases in Yunnan[J]. Chin J Exp Clin Virol,2017,31(1):24-30. DOI:10.3760/cma.j.issn.1003-9279.2017.01.005.(in Chinese)(5):428-432. DOI:10.3760/cma.j.issn.0254-6450.2013.05.004.Zhang HL,Fu SH,Deng Z,et al. An outbreak of imported dengue fever from Myanmar to the border of China,with its viral molecular epidemiological features[J]. Chin J Epidemiol,2013,34(5):428-432. DOI:10.3760/cma.j.issn.0254-6450.2013. 05.004.(in Chinese)
[17] Cuong HQ,Vu NT,Cazelles B,et al. Spatiotemporal dynamics of dengue epidemics,southern Vietnam[J]. Emerg Infect Dis,2013,19(6):945-953. DOI:10.3201/eid1906.121323.
[18] 牟笛,何泱霓,陈秋兰,等. 我国2016年登革热输入和本地病例流行病学特征比较[J]. 疾病监测,2017,32(3):184-189. DOI:10.3784/j.issn.1003-9961.2017.03.004.Mu D,He YN,Chen QL,et al. Comparison of epidemiological features between imported and indigenous dengue cases in China[J]. Dis Surveill,2017,32(3):184-189. DOI:10.3784/j.issn. 1003-9961.2017.03.004.(in Chinese)
[19] 刘昶权,张国明,韦广莹,等. 2019年广东省480例登革热住院患者的流行病学和临床特征分析[J]. 中华传染病杂志,2021,39(4):209-213. DOI:10.3760/cma.j.cn311365-20200220-00093.Liu CQ,Zhang GM,Wei GY,et al. Analysis of epidemiological characteristics and clinical features of 480 hospitalized patients with dengue fever in Guangdong province in 2019[J]. Chin J Infect Dis,2021,39(4):209-213. DOI:10.3760/cma.j.cn311365-20200220-00093.(in Chinese)
[20] 魏春,郭小连,杨锐,等. 云南省2013-2020年登革热流行及聚集特征分析[J]. 中国媒介生物学及控制杂志,2021,32(6):720-724,743. DOI:10.11853/j.issn.1003.8280.2021.06.013.Wei C,Guo XL,Yang R,et al. Epidemiological and cluster characteristics of dengue fever in Yunnan province,China,2013-2020[J]. Chin J Vector Biol Control,2021,32(6):720-724,743. DOI:10.11853/j.issn.1003.8280.2021.06.013.(in Chinese)
[21] 王晶,罗飞,何为涛,等. 广西壮族自治区2016-2020年登革热流行特征分析[J]. 中国媒介生物学及控制杂志,2023,34(1):65-69. DOI:10.11853/j.issn.1003.8280.2023.01.012.Wang J,Luo F,He WT,et al. Epidemiological characteristics of dengue fever in Guangxi Zhuang Autonomous Region,China,2016-2020[J]. Chin J Vector Biol Control,2023,34(1):65-69. DOI:10.11853/j.issn.1003.8280.2023.01.012.(in Chinese)
[22] 范建华,冯云,朱进,等. 2017年云南省西双版纳州登革1型病毒暴发疫情的调查研究[J]. 疾病监测,2019,34(5):427-434. DOI:10.3784/j.issn.1003-9961.2019.05.013.Fan JH,Feng Y,Zhu J,et al. An outbreak of Dengue serotype 1 virus in Xishuangbanna prefecture of Yunnan province,China,2017[J]. Dis Surveill,2019,34(5):427-434. DOI:10.3784/j.issn.1003-9961.2019.05.013.(in Chinese)
[23] 杨锐,罗燕,冯志刚,等. 中缅边境地区一起登革热暴发疫情调查分析[J]. 中国病原生物学杂志,2021,16(2):228-230. DOI:10.13350/j.cjpb.210220.Yang R,Luo Y,Feng ZG,et al. Analysis and investigation of one outbreak of dengue fever in the border areas of Yunnan,PR China with Myanmar[J]. J Parasit Biol,2021,16(2):228-230. DOI:10.13350/j.cjpb.210220.(in Chinese)
