蜱Kunitz型蛋白酶抑制剂的抗凝机制研究进展

马静, 高金亮

doi:10.11853/j.issn.1003.8280.2021.01.024

中国媒介生物学及控制杂志 >

2021 , Vol. 32 >Issue 1: 111 - 114

DOI: https://doi.org/10.11853/j.issn.1003.8280.2021.01.024

综述

蜱Kunitz型蛋白酶抑制剂的抗凝机制研究进展

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1. 鄂尔多斯市中心医院分子医学实验室, 内蒙古鄂尔多斯 017000;
2. 包头医学院, 内蒙古包头 014040

马静,女,在读硕士,主要从事蜱源抗凝血物质的筛选与鉴定工作,E-mail:574398648@qq.com

收稿日期: 2020-07-24

网络出版日期: 2021-02-20

基金资助

内蒙古自然科学基金（2016MS08113）；国家自然科学基金（81760375）；鄂尔多斯市产业创新人才团队项目（鄂人才办字［2016］11号）

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Research advances in anticoagulant mechanisms of tick-derived protease inhibitors containing the Kunitz domain

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1. Laboratory of Molecular Medicine, Ordos Central Hospital, Ordos, Inner Mongolia 017000, China;
2. Baotou Medical College, Baotou, Inner Mongolia 014040, China

Received date: 2020-07-24

Online published: 2021-02-20

Supported by

Supported by the Natural Science Foundation of Inner Mongolia of China (No. 2016MS08113), National Natural Science Foundation of China (No. 81760375) and the Program for Entrepreneurial and Innovative Talent Team of Ordos (Ordos talent office[2016] No. 11)

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摘要

蜱是一类体外吸血寄生虫，在长期吸血的过程中蜱向宿主体内释放多种抗凝血物质来阻止宿主血液凝固。含有Kunitz结构域的丝氨酸蛋白酶抑制分子是蜱分泌的重要抗凝血物质。不同蜱种体内的抗凝血物质释放的部位、作用的凝血因子以及与凝血因子相结合的位点各有不同。通过对现有蜱源Kunitz结构域的抗凝血物质的综述，为今后发现更多的蜱源Kunitz型抗凝血物质，并在药理水平上研究蜱与宿主之间相互作用的机制提供参考。

关键词： 蜱; 抗凝血; Kunitz结构域; 丝氨酸蛋白酶抑制剂

本文引用格式

马静, 高金亮 . 蜱Kunitz型蛋白酶抑制剂的抗凝机制研究进展[J]. 中国媒介生物学及控制杂志, 2021 , 32(1) : 111 -114 . DOI: 10.11853/j.issn.1003.8280.2021.01.024

Abstract

Ticks are blood-sucking ectoparasites that release a variety of anticoagulant substances to their hosts to prevent blood clotting for the convenience of their blood feeding. Serine protease inhibitors containing Kunitz domain secreted by ticks are important anticoagulant substances. For different ticks, various anticoagulant substances are produced in different organs targeting their specific coagulation factors at different binding sites. This article reviews the existing tick-derived anticoagulant substances containing the Kunitz domain, so as to provide a reference for discovering more such anticoagulant substances in tick origin in the future and studying the mechanism of tick-host interaction at the pharmacological level.

Key words： Tick; Anticoagulant; Kunitz domain; Serine protease inhibitor

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