目的 加强基层医院犬伤门诊建设与管理,进一步规范狂犬病暴露预防处置工作。方法 收集2009-2019年期间嘉兴市疾病预防控制中心(CDC)犬伤门诊资料,运用Excel 2007软件处理监测资料并进行回顾性分析,提出狂犬病暴露预防处置中存在的问题。结果 嘉兴市CDC犬伤门诊暴露人数呈逐年递增趋势,11年共接诊暴露者66 059例,男女性别比为0.93:1。7-8月为暴露高峰,82.50%的暴露者在24 h内及时就诊。Ⅲ级暴露者中人狂犬病免疫球蛋白联合注射率由2009年的10.02%逐年上升至2019年的63.42%,平均注射率为41.91%。存在犬伤门诊硬件设施落后,专职执业医师配备不足,问诊信息不详尽,知情同意不到位,暴露处置欠规范,暴露者依从性不高,重症患者转送机制不畅通,信息化管理薄弱,以及对暴露者的健康教育以及心理辅导缺位等问题。结论 嘉兴市CDC由原来的狂犬病暴露预防处置承担单位转型为对基层医院的技术管理和指导单位,基层医院需加强犬伤门诊基础建设,配备足够数量的具有相应资质的犬伤门诊专职医务人员,加强信息化建设,优化犬伤门诊服务制度。
Objective To strengthen the construction and management of the outpatient service of rabies in primary hospitals, and to further standardize the prevention and disposal of rabies exposure. Methods The data of rabies exposure in the outpatient service of Jiaxing Center for Disease Control and Prevention (Jiaxing CDC) were collected from 2009 to 2019, and Excel 2007 software was used to perform a retrospective analysis of the data. The problems in the prevention and disposal of rabies exposure were put forward. Results In the outpatient service of Jiaxing CDC, the number of individuals with rabies exposure was increasing year by year, and 66 059 individuals with rabies exposure were received in the past 11 years, with a male/female ratio of 0.93:1. The peak of rabies exposure was in July and August, and 82.50% of the exposed individuals attended the hospital within 24 hours. The rate of combined injection of rabies immunoglobulin increased from 10.02% in 2009 to 63.42% in 2019 among the individuals with grade Ⅲ exposure, and the mean injection rate was 41.91%. There were several problems in the outpatient service of rabies, such as old hardware facilities, insufficient number of full-time medical practitioners, a lack of detailed inquiry information, inadequate informed consent, a lack of standard exposure treatment, low compliance of individuals with exposure, poor transfer mechanism of severe patients, weak information management, and a lack of health education and psychological guidance for individuals with exposure. Conclusion Jiaxing CDC has transformed from the unit undertaking the prevention and disposal of rabies exposure to the unit of the technical management and guidance of primary hospitals. Primary hospitals need to strengthen the infrastructure of the outpatient service of rabies, equip enough qualified full-time medical staffs, improve information construction, and optimize the outpatient service system for rabies.
[1] 周航,李昱,陈瑞丰,等. 狂犬病预防控制技术指南(2016版)[J]. 中华流行病学杂志,2016,37(2):139-163. DOI:10.3760/cma.j.issn.0254-6450.2016.02.001. Zhou H,Li Y,Chen RF,et al. Technical guideline for human rabies prevention and control (2016)[J]. Chin J Epidemiol,2016,37(2):139-163. DOI:10.3760/cma.j.issn.0254-6450.2016.02.001.
[2] 中国疾病预防控制中心. 狂犬病暴露预防处置操作指南(2007)[M/OL]. (2007-12-01)[2020-04-10]. http://guide.medlive.cn/guideline/846. Chinese Center for Disease Control and Prevention. Operation guide for prevention and disposal of rabies exposure(2007)[M/OL].(2007-12-01)[2020-04-10]. http://guide.medlive.cn/guideline/846.
[3] 中华人民共和国国家卫生健康委员会. 狂犬病暴露预防处置工作规范(2009年版)[EB/OL].(2009-12-17)[2020-04-10]. http://www.nhc.gov.cn/bgt/s10695/200912/79bceb43bd6444d1bfabbdd37f931267.shtml. National Health Commission of the People's Republic of China. Standard of prevention and disposal for rabies exposure (Edition 2009)[EB/OL]. (2009-12-17)[2020-04-10].http://www.nhc.gov.cn/bgt/s10695/200912/79bceb43bd6444d1bfabbdd37f931267.shtml.
[4] 茅蓉,曹家穗,金安宝. 2009-2014年浙江省嘉兴市疾病预防控制中心犬伤门诊狂犬病暴露人群监测分析[J]. 疾病监测,2015,30(10):851-854. DOI:10.3784/j.issn.1003-9961.2015.10.014. Mao R,Cao JS,Jin AB. Rabies surveillance in rabies clinic affiliated to Jiaxing prefecture center for disease control and prevention,2009-2014[J]. Dis Surveill,2015,30(10):851-854. DOI:10.3784/j.issn.1003-9961.2015.10.014.
[5] 闻栋. 湖州市狂犬病暴露人群流行特征与暴露预防处置现状分析[J]. 中国高等医学教育,2015(5):129,139. DOI:10.3969/j.issn.1002-1701.2015.05.068. Wen D. Analysis of the current situation of rabies exposure and its prevention and treatment in Huzhou city[J]. China High Med Educ,2015(5):129,139. DOI:10.3969/j.issn.1002-1701.2015.05.068.
[6] 丁春喜,黄健,朱敏. 嘉善县2012-2016年狂犬病暴露人群流行病学特征分析[J]. 中国乡村医药,2018,25(21):52-53. DOI:10.3969/j.issn.1006-5180.2018.21.033. Ding CX,Huang J,Zhu M. Epidemiological characteristics of rabies exposed population in Jiashan county from 2012 to 2016[J]. Chin J Rural Med Pharm,2018,25(21):52-53. DOI:10.3969/j.issn.1006-5180.2018.21.033.
[7] 曾权威,官映清,邓思民,等. 11200例狂犬病暴露人群预防处置情况分析[J]. 海南医学,2018,29(13):1899-1901. DOI:10.3969/j.issn.1003-6350.2018.13.038. Zeng QW,Guan YQ,Deng SM,et al. Analysis on prevention and treatment of rabies exposed population:11200 cases[J]. Hainan Med J,2018,29(13):1899-1901. DOI:10.3969/j.issn.1003-6350.2018.13.038.
[8] 王玮,林君芬,柴程良,等. 浙江省2011年犬伤门诊规范化建设现况调查分析[J]. 中国媒介生物学及控制杂志,2013,24(6):531-534. DOI:10.11853/j.issn.1003.4692.2013.06.016. Wang W,Lin JF,Chai CL,et al. Investigation of standardized development of dog bite injury clinics in Zhejiang province,China in 2011[J]. Chin J Vector Biol Control,2013,24(6):531-534. DOI:10.11853/j.issn.1003.4692.2013.06.016.
[9] 任江萍,凌峰,龚震宇,等. 浙江省犬伤门诊服务现状分析[J]. 预防医学,2017,29(1):53-55,59. DOI:10.19485/j.cnki.issn1007-0931.2017.01.013. Ren JP,Ling F,Gong ZY,et al. Analysis on the current situation of dog injury outpatient service in Zhejiang province[J]. Prev Med, 2017,29(1):53-55,59. DOI:10.19485/j.cnki.issn1007-0931.2017.01.013.
[10] 张英,印庆华,杨玲玲. 上海市嘉定区35253例狂犬病暴露病例流行病学分析[J]. 中国临床医学,2019,26(2):315-317. DOI:10.12025/j.issn.1008-6358.2019.20190205. Zhang Y,Yin QH,Yang LL. Epidemiological analysis of 35253 cases of rabies exposure in Jiading district of Shanghai[J]. Chin J Clin Med,2019,26(2):315-317. DOI:10.12025/j.issn.1008-6358.2019.20190205.
[11] 吕敬奇. 狂犬病暴露人群的规范处置及其流行病学分析[J]. 中国社区医师,2018,34(19):174,176. DOI:10.3969/j.issn.1007-614x.2018.19.107. Lyu JQ. Standardized disposal and epidemiological analysis of population exposed to rabies[J]. Chin Commun Doctors,2018, 34(19):174,176. DOI:10.3969/j.issn.1007-614x.2018.19.107.
[12] 李芳,付美华,陈水芳,等. 2014-2017年浙江省常山县狂犬病暴露病例流行病学特征与伤情分析[J]. 现代实用医学,2019,31(4):498-500. DOI:10.3969/j.issn.1671-0800.2019.04.034. Li F,Fu MH,Chen SF,et al. Epidemiological characteristics and injury analysis of rabies exposure cases in Changshan county,Zhejiang province,2014-2017[J]. Mod Pract Med,2019,31(4):498-500. DOI:10.3969/j.issn.1671-0800.2019.04.034.
[13] 王传林. 狂犬病疫苗免疫程序的演变[J]. 中华实验和临床病毒学杂志,2018,32(4):440-444. DOI:10.3760/cma.j.issn.1003-9279.2018.04.024. Wang CL. Evolution of rabies vaccination regimen[J]. Chin J Exp Clin Virol,2018,32(4):440-444. DOI:10.3760/cma.j.issn.1003-9279.2018.04.024.
[14] 佟丽,王传林,张怡滨,等. 我国狂犬病暴露后"2-1-1"免疫程序研发及应用分析[J]. 中国急救复苏与灾害医学杂志,2018,13(11):1156-1158. DOI:10.3969/j.issn.1673-6966.2018.11.030. Tong L,Wang CL,Zhang YB,et al. Development and application of "2-1-1" immune program after rabies exposure in China[J]. Chin J Emerg Resusc Disaster Med,201813(11):1156-1158. DOI:10.3969/j.issn.1673-6966.2018.11.030.