目的 了解四川省登革热传播媒介白纹伊蚊成蚊对常用杀虫剂的抗药性水平，为指导登革热暴发后正确地选择和使用卫生杀虫剂，快速降低传播媒介密度，提高防制效果提供依据。方法 选取成都等10个市，于2019年6月分别在城区各处采集白纹伊蚊幼蚊，带回实验室饲养；待羽化为成蚊后，采用世界卫生组织推荐的接触筒法，将获得数据依据判定标准进行分析，评价是否产生抗药性。结果 调查结果显示，成都、雅安、乐山、攀枝花、南充、遂宁、内江、自贡、泸州和广安市白纹伊蚊成蚊暴露于0.40%高效氯氰菊酯、0.10%溴氰菊酯、0.50%马拉硫磷和0.05%残杀威中各1和24 h，死亡率分别为29.00%~98.40%、22.91%~98.85%、33.11%~100%和89.91%~100%。大部分监测点白纹伊蚊成蚊对高效氯氰菊酯和溴氰菊酯呈抗性水平；除成都、雅安和遂宁市外，其他监测点试虫对马拉硫磷均敏感；所有监测点试虫对残杀威敏感。结论 应对调查地区停止或减少使用拟除虫菊酯类杀虫剂，改用有机磷类和氨基甲酸酯类杀虫剂，或2类杀虫剂轮换使用，以减缓抗药性水平的发展并保护环境。
Objective To investigate resistance levels of the dengue vector adult Aedes albopictus to commonly used insecticides in Sichuan province, China, and to provide a basis for guiding the selection and use of insecticides after dengue outbreak, rapidly reducing the density of vector, and improving the control effect. Methods The larvae of Ae. albopictus were captured at different sites in the urban areas of 10 cities or prefectures in Sichuan province including Chengdu, in June, 2019, and brought them back to the laboratory for feeding. After becoming adult mosquitoes, they were tested by the contact tube method recommended by the World Health Organization, and the data obtained were analyzed according to the judgment criteria to evaluate whether they had resistance to insecticides. Results The adult mosquitoes from Chengdu, Ya'an, Leshan, Panzhihua, Nanchong, Suining, Neijiang, Zigong, Luzhou, and Guang'an were exposed to 0.40% beta-cypermethrin, 0.10% deltamethrin, 0.50% malathion, and 0.05% propoxur for 1 and 24 hours, respectively, with mortality rates of 29.00%-98.40%, 22.91%-98.85%, 33.11%-100%, and 89.91%-100%, respectively. Adult mosquitoes at most surveillance sites were resistant to beta-cypermethrin and deltamethrin; the test mosquitoes at all surveillance sites except those in Chengdu, Ya'an, and Suining were sensitive to malathion; the test mosquitoes at all surveillance sites were sensitive to propoxur. Conclusion It is suggested that in these regions, the use of pyrethroid insecticides should be stopped or reduced, while organophosphate and carbamate insecticides should be used together or alternately to reduce the development of insecticide resistance in Ae. albopictus and protect the environment.
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