目的 评估2010－2019年中国登革热的疾病负担，为登革热防控策略措施制定和完善卫生资源的合理配置提供依据。方法 采用世界卫生组织提出的方法，结合我国法定传染病监测系统报告病例数据，应用伤残损失寿命年（YLD）、早死损失寿命年（YLL）及伤残调整寿命年（DALY）指标估算我国登革热疾病负担。结果 2010－2019年间，我国共报告91 555例登革热病例，死亡13例；病例主要集中在15~59岁，占总病例数的77.32%。归因于登革热的YLL负担累计为179人年，YLD负担累计为3 434人年，DALY负担累计为3 613人年，标化后人口的DALY为2.71人年/100万。2010－2019年DALY负担水平变化较大，由9人年增至883人年。男性与女性归因于登革热的DALY负担水平大体一致，男性DALY负担水平略高于女性，男女性比例为1.06：1。归因于登革热的疾病负担在每个年龄段均有分布，主要集中在15~、30~、45~岁3个年龄段，构成比>85%。结论 2010－2019年中国登革热疾病负担总体呈上升趋势，对人群造成的风险不断增加，建议进一步加强登革热监测和风险评估，优化卫生资源配置，为其可持续控制提供科学依据。
Objective To assess the disease burden of dengue fever in China from 2010 to 2019, and to provide a basis for formulating strategies for dengue fever prevention and control and improving the rational allocation of health resources. Methods With reference to the case data reported in China's National Notifiable Infectious Disease Surveillance System, the method proposed by the World Health Organization was used to estimate the disease burden of dengue fever in China based on the indicators of years lived with disability (YLD), years of life lost (YLL), and disability-adjusted life years (DALY). Results A total of 91 555 cases of dengue fever, including 13 deaths, were reported in China from 2010 to 2019. Most patients were aged 15-59 years, accounting for 77.32%. The cumulative YLL burden attributable to dengue fever was 179 person-years, the cumulative YLD burden was 3 434 person-years, the cumulative DALY burden was 3 613 person-years, and the normalized DALY was 2.71 person-years per million population. From 2010 to 2019, DALY burden greatly increased from 9 person-years to 883 person-years. The DALY burden due to dengue fever was similar between male and female individuals, and male individuals had a slightly higher DALY burden than female individuals, with a male/female ratio of 1.06:1. The disease burden attributable to dengue fever was distributed in all age groups, mainly 15-29 years, 30-44 years, and 45-59 years, with a constituent ratio of >85%. Conclusion The disease burden of dengue fever in China tends to increase from 2010 to 2019, causing increasing risks to the population. It is recommended to further strengthen the surveillance and risk assessment of dengue fever and optimize the allocation of health resources, so as to provide a scientific basis for sustainable control of this disease.
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