杭州市2018年一起农村登革热暴发疫情调查研究

孙昼, 陈珺芳, 竹军伟, 考庆君, 黄仁杰, 汪皓秋

doi:10.11853/j.issn.1003.8280.2020.04.018

中国媒介生物学及控制杂志 >

2020 , Vol. 31 >Issue 4: 465 - 468

DOI: https://doi.org/10.11853/j.issn.1003.8280.2020.04.018

调查研究

杭州市2018年一起农村登革热暴发疫情调查研究

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1 杭州市疾病预防控制中心传染病防制所, 浙江杭州 310021;
2 余杭区疾病预防控制中心, 浙江余杭 311000

孙昼,男,主任医师,主要从事急性传染病疫情处置工作,Email:hzcdc@qq.com

收稿日期: 2020-03-22

网络出版日期: 2020-08-20

基金资助

浙江省医药卫生科技计划面上项目（2020KY236，2019KY146）；杭州市农业与社会发展科研主动设计项目（20190101A12）

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An investigation of a dengue outbreak in a rural area in Hangzhou, Zhejiang province, China, 2018

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1 Hangzhou Center for Disease Control and Prevention, Hangzhou 310021, Zhejiang Province, China;
2 Yuhang District Center for Disease Control and Prevention

Received date: 2020-03-22

Online published: 2020-08-20

Supported by

Supported by the Medicine and Health Science and Technology Plan Project of Zhejiang Province (No. 2020KY236, 2019KY146) and Research of Agricultural and Social Development Project of Hangzhou (No. 20190101A12)

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摘要

目的对杭州市一起农村登革热暴发疫情开展调查与分析，为制订农村登革热防控措施提供科学依据。方法采用描述性流行病学方法分析2018年9月杭州市农村一起登革热的流行病学特征；采集患者血清进行登革病毒核酸和抗体检测，提取病毒核酸后扩增E基因并测序，构建进化树；采用布雷图指数（BI）法进行蚊媒密度监测。结果该起疫情共报告登革热本地病例13例，罹患率为0.13%；其中，发病年龄最小30岁，最大79岁，以50岁以上人群为主；职业分布以农民居多。5株登革病毒株经序列分析，均属登革病毒1型，与泰国和缅甸等东南亚国家登革病毒1型同源性高。结论该起农村登革热本地暴发疫情由登革病毒1型引起，传染源可能来自东南亚国家，相关部门应进一步加强登革热输入病例监测。

关键词： 登革热; 暴发疫情; 流行病学调查

本文引用格式

孙昼, 陈珺芳, 竹军伟, 考庆君, 黄仁杰, 汪皓秋 . 杭州市2018年一起农村登革热暴发疫情调查研究[J]. 中国媒介生物学及控制杂志, 2020 , 31(4) : 465 -468 . DOI: 10.11853/j.issn.1003.8280.2020.04.018

Abstract

Objective To investigate a dengue outbreak in a rural area in Hangzhou, Zhejiang province, China, and to provide a scientific basis for dengue control and prevention in rural areas. Methods The descriptive epidemiological method was used to analyze the epidemiological characteristics of the dengue outbreak in rural Hangzhou in September 2018. The serum samples from the dengue patients were collected to detect viral nucleic acids and antibodies, and the viral nucleic acids were extracted for E gene amplification and sequencing to construct a phylogenetic tree. The density of mosquitoes was monitored by the Breteau index. Results There were 13 local cases of dengue reported, and the attack rate was 0.13%. The patients were aged 30 to 79 years, mainly over 50 years. Most of them were farmers. Five virus isolates were identified as dengue virus type I by sequence analysis, highly homologous to the type 1 dengue viruses from Southeast Asian countries including Thailand and Myanmar. Conclusion Type 1 dengue virus is responsible for this local outbreak of dengue in rural Hangzhou, and possibly comes from Southeast Asian countries. Relevant authorities should further strengthen monitoring of imported dengue cases.

Key words： Dengue fever; Outbreak; Epidemiological investigation

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