目的 调查杭州市2017年登革热疫情应急控制前后白纹伊蚊成蚊对常用杀虫剂的抗性变化，探索化学杀虫剂应急处置对蚊虫抗药性的影响。方法 2017年8月底登革热暴发初期采集杭州市各疫点的白纹伊蚊幼虫，11月登革热疫情应急控制后期采集下城区朝晖九区的白纹伊蚊幼虫，分别于实验室饲养至成蚊，采用世界卫生组织推荐的成蚊接触筒法测定其抗药性。结果 杭州市登革热疫情初期白纹伊蚊成蚊对高效氯氰菊酯、溴氰菊酯、残杀威、马拉硫磷、顺式氯氰菊酯和氯菊酯均敏感，24 h死亡率均为100%，对杀螟硫磷和高效氯氟氰菊酯为可疑抗性，死亡率分别为88.46%和96.00%。经过大面积控制后，白纹伊蚊对高效氯氰菊酯、杀螟硫磷和马拉硫磷均产生抗药性，死亡率分别为73.81%、72.29%和17.07%，对溴氰菊酯、顺式氯氰菊酯、高效氯氟氰菊酯和氯菊酯为可疑抗性，死亡率分别为86.08%、90.48%、91.30%和80.52%，仅对残杀威敏感，死亡率为98.77%。结论 短期大量使用杀虫剂会使白纹伊蚊的抗药性迅速增加，因此在蚊媒应急控制中应根据抗药性监测结果，科学合理使用杀虫剂，适当轮换用药，以预防或延缓抗药性的产生，倡导媒介伊蚊可持续控制。

Objective To investigate the changes in resistance of adult Aedes albopictus to common insecticides before and after emergency control of dengue fever in Hangzhou in 2017, and to explore the impacts of emergency chemical insecticide treatment on the insecticide resistance of mosquitoes. Methods Aedes albopictus larvae from every epidemic spot in Hangzhou were collected at the end of August, 2017, the early stage of dengue fever outbreak. In November, when the emergency control of dengue fever was in the late stage, Ae. albopictus larvae were collected from Zhaohui Nine Community in Xiacheng district. Both batches of Ae. albopictus were reared in the lab, and their insecticide resistance was determined by the adult contact tube method, which is recommended by WHO. Results In the early stage of dengue fever outbreak in Hangzhou, adult Ae. albopictus was sensitive to beta-cypermethrin, deltamethrin, propoxur, malathion, alpha-cypermethrin, and permethrin, with a 24-hour mortality rate of 100%. There was suspicious resistance to fenitrothion and lambda-cyhalothrin, and the mortality rates were 88.46% and 96.00%, respectively. After a large-scale insecticidal control, Ae. albopictus developed resistance to beta-cypermethrin, fenitrothion, and malathion at the end of emergency control, and the mortality rates were 73.81%, 72.29%, and 17.07%, respectively. In addition, they developed suspicious resistance to deltamethrin, alpha-cypermethrin, lambda-cyhalothrin, and permethrin, with mortality rates of 86.08%, 90.48%, 91.30%, and 80.52%, respectively. They remained sensitive to only propoxur, with a mortality rate of 98.77%. Conclusion Large-scale use of insecticides within a short period will increase the resistance of Ae. albopictus to insecticides. Therefore, in emergency control of mosquitoes, pesticides should be used scientifically and rationally based on the results of drug resistance monitoring, and an appropriate rotation strategy should be applied to prevent or delay the development of insecticide resistance. Additionally, sustainable management of Ae. albopictus vector should be advocated.