目的 探讨河北省动物鼠疫疫区处理经验。方法 以河北省2017－2018年动物鼠疫疫区处理灭鼠、灭蚤为主的方法，总结分析动物鼠疫疫区处理的效果和意义。结果 河北省动物鼠疫疫区处理共投放毒饵350.0 kg、灭鼠烟剂2 495.6 kg；疫点处理效果考核密度为0只/hm²；动物鼠疫疫情得到有效控制，未波及到人间。结论河北省动物鼠疫疫区，灭鼠、灭蚤为主的综合措施可有效控制和消除动物鼠疫波及人间的风险。

Objective To explore the handling experience in the animal plague epidemic area in Hebei province, China. Methods Based on the main measure rat and flea control in the animal plague epidemic area of Hebei province from 2017 to 2018, the handling effectiveness and significance were summarized and analyzed. Results A total of 350.0 kg poisonous rodent bait and 2 495.6 kg deratization fumigant were dropped in the animal epidemic area of Hebei province. The examined rodent density in the epidemic area was 0 inds/hm². The animal plague epidemic was effectively controlled and did not affect humans. Conclusion The integrated measure based on rat and flea control can effectively control and prevent the human plague risk in the animal plague epidemic area in Hebei province, China.