目的 掌握天津市东丽区家蝇对4种杀虫剂的抗药性现状及发展趋势，为科学、合理选用杀虫剂提供依据。方法 分别于2014和2017年采集天津市东丽区野外家蝇，采用点滴法测定其对高效氯氰菊酯、溴氰菊酯、氯菊酯和残杀威4种杀虫剂的抗药性，利用SPSS 19.0统计软件计算半数致死量（LD₅₀）、95% CI，建立毒力回归方程分析并比较其抗药性发展趋势。结果 2014、2017年东丽区家蝇对高效氯氰菊酯、溴氰菊酯、氯菊酯、残杀威的抗性倍数依次为1.75～3.75、1.00～15.00、36.75～40.00和3.41～29.50倍。其中家蝇对氯菊酯和残杀威呈现高抗，对溴氰菊酯呈现中抗，对高效氯氰菊酯为敏感或低抗。结论 天津市东丽区家蝇对4种杀虫剂均产生了不同程度的抗药性并呈现升高趋势，建议科学合理选择杀虫剂，控制和延缓家蝇抗药性发展。

Objective To understand the present situation and trend of resistance in Musca domestica to four types of insecticides in Dongli district of Tianjin in recent years, and to provide a scientific basis for better use of insecticides. Methods Musca domesticas were collected outdoors in Dongli district during 2014 to 2017, the resistance of M. domestica to β-cypermethrin, deltamethrin, permethrin and propoxur were determined by topical application method, and data were analyzed by SPSS 19.0 software for LD₅₀ and its confidential intervals (CI). The regression equation was established to evaluate resistance development trend. Results The resistance ratios of M. domestica in Dongli district during 2014 to 2017 to β-Cypermethrin, deltamethrin, permethrin and propoxur were 1.75-3.75, 1.00-15.00, 36.75-40.00, and 3.41-29.50 fold, respectively. Musca domestica in Dongli district has developed severe resistance to permethrin and propoxur, moderate to deltamethrin, and mild even susceptible to β-Cypermethrin. Conclusion Musca domestica in Dongli district of Tianjin has developed different degrees of resistance to four types of insecticides and the trend was upward. It is suggested that insecticides should be used scientifically based on the susceptibility monitoring, in order to prevent and delay the development of resistance.