目的 评价溴敌隆在云南省野鼠鼠疫疫区处置中的灭鼠效果，为鼠类控制及鼠疫防治提供基础数据。方法 2017年4-5月选择云南省丽江市玉龙县、古城区和大理白族自治州剑川县、鹤庆县居民区及耕地两种生境，使用0.5%溴敌隆母液配制0.005%的小麦毒饵，采取"回合式"投药，采用不设对照区的鼠疫流行疫点区和设对照区的非疫点区分别进行灭鼠效果试验。利用Excel 2010和SPSS 18.0软件对调查数据进行统计分析，灭鼠率的比较采用χ²检验。结果 鼠疫流行疫点居民区灭鼠率为77.67%~100%，耕地为88.89%~100%；设对照区的非疫点居民区灭鼠率为88.48%~100%，耕地为85.72%~97.74%。疫点区和非疫点区同一生境不同县（区）及4个县（区）不同生境灭鼠率差异均无统计学意义（χ²=0.800、0.863，均P > 0.05），两种试验设计方法计算居民区和耕地的灭鼠率差异均无统计学意义（χ²=1.507、0.050，均P > 0.05）。结论 溴敌隆杀鼠剂对云南省家栖和野栖鼠类仍具有良好的毒杀作用，且适口性较好，在鼠疫疫区处置过程中可有效降低鼠密度，防止鼠疫疫情蔓延。目前仍可用于云南省家、野鼠两型鼠疫疫区及大面积控制鼠害。

Objective To evaluate the effect of rodent control by bromadiolone in the plague epidemic area, provide basic data for rodent control and plague prevention. Methods In Yulong county, Gucheng district,Jianchuan county and Heqing county residential area and cultivated land in two habitats, 0.005% wheat bait was prepared with 0.5% bromadiolone and applied to project area of the plague epidemic area and non-epidemic area of the control during April to May 2017. Results The killing effect of plague epidemic residential area was 77.67%-100%, cultivated land 88.89%-100%; In control of non-epidemic residential area, killing effect was 88.48%-100%, cultivated 85.72%-97.74%. As to the same habitat in epidemic area and non-epidemic area in different counties, there were no statistical differences in the efficacy of different habitats in 4 counties and cities(χ²=0.800, 0.863, P > 0.05). Two kinds of experimental design methods were used to calculate the effect of residential area and cultivated land, and there was no statistical significance (χ²=1.507, 0.050, P > 0.05). Conclusion In Yunnan provincial residential area and wild animal habitats, bromadiolone still has good effect as poison baits. In the process of plague epidemic disposal, the population density of rats can be effectively reduced, and the spread of plague epidemic can be prevented. It can be utilized in control of commensal and wild rodents to prevent the two types of plague epidemics.