10、74、107 kb 3种质粒形成了我国各鼠疫自然疫源地内鼠疫耶尔森菌（鼠疫菌）主要质粒图谱，在国内不同疫源地又陆续发现了不同质粒，有16种不同类型，这些质粒分别具有不同的功能。质粒在自然界中容易自然缺失或丢失而使鼠疫菌性状发生变异，也是每次鼠疫流行末期自然终止流行和鼠疫流行静息期存在的原因之一。该文就鼠疫菌质粒变异对鼠疫流行的影响进行了探讨，以供人们对鼠疫流行规律进行研究。
There are three plasmids of 10, 74, 107 kb which are main plasmids of Yersinia pestis in the plague natural foci of China. Different plasmids have been found in China and there are 16 different types. Plasmid in nature is easy to be lost and Y. pestis is therefore altered. This is also the cause of natural death at the end of plague and circulating of the plague. Plasmid variation of the Y. pestis is discussed for the plague epidemic. The study of the law of epidemic plague is useful for public health.
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