目的 对河北省鼠疫高危地区人群血清鼠疫F1抗体进行延续性调查，进一步了解鼠疫高危地区人群鼠疫感染情况。方法 根据康保县、蠡县和张家口市区人口资料，2016年1-6月，选择鼠疫高危地区人群采血分离血清；用IHA、胶体金免疫层析法及ELISA检测鼠疫F1抗体水平。结果 采集康保县及蠡县高危人群血清样本7204份，采用上述3种检测方法，结果均为阴性；100份对照血清用同样方法进行检测，结果也为阴性。2007年在康保县调查时检出阳性4份（4/196）。结论 近期在张家口市康保县和保定市蠡县鼠疫高危人群中无鼠疫感染者，即未发生人间鼠疫。

Objective To investigate the prevalence of plague F1 antibody in the population of high risk area of plague in Hebei province, and further understand the situation of plague infection. Methods According to population data of Kangbao and Lixian counties, 7 204 sampling population were selected in January to June 2016. Serum samples were collected from blood. Plague F1 antibody of serum blood was tested by IHA, colloidal gold immunochromatographic assay and ELISA. Results These serum samples from the high risk population of two counties were collected, and tested negative by the three methods. In total, 100 control sera were detected by the same method and the results were also negative. Four positive results were found in Kangbao county in 2007. Conclusion In recent years, there was no plague positive infection among the high risk population in Zhangjiakou and Lixian.