目的 掌握福建省肾综合征出血热（HFRS）疫情动态，为防制工作提供科学依据。方法 对2013-2015年福建省疫情报告进行统计分析；采用笼夜法捕获鼠形动物，计算鼠密度及构成比，应用免疫荧光法对鼠肺进行汉坦病毒（HV）抗原检测及分型。结果 2013-2015年福建省报告HFRS患者1 309例，平均发病率为1.16/10万。疫情分布广泛，邵武、晋江、石狮市发病数位居全省前3位，邵武市、松溪、政和及周宁县发病率均>5/10万。室内平均鼠密度为6.83%，褐家鼠为主要鼠种，其携带汉城型HV（SEOV）；混合型疫区野外平均鼠密度为5.60%，黑线姬鼠为主要鼠种；首次从云霄、清流和明溪县的褐家鼠及黄胸鼠中检出HV抗原。结论 福建省HFRS的宿主动物以褐家鼠为主。2013-2015年福建省HFRS疫情严重，邵武市、松溪、政和及周宁县的HFRS发病率均高于中发县，应做好防鼠灭鼠工作，对重点人群推广使用HFRS双价疫苗，降低发病率，严防鼠传疾病暴发流行。

Objective To investigate the epidemic of hemorrhagic fever with renal syndrome(HFRS) in Fujian province, China and to provide a scientific basis for the prevention and control of this disease. Methods The data on the epidemic of HFRS in 2013-2015 in Fujian province were subjected to statistical analysis. Rodents were captured using cages at night, and the population density and community structure of captured rodents was determined. Hantavirus(HV) antigen was detected and identified from rodent lungs by indirect immunofluorescence assay. Results A total of 1 309 cases of HFRS were reported in Fujian in 2013-2015, with an incidence of 1.16/100 000. The cases were widely distributed, county-level cities, or districts. The cases of HFRS were the highest in Shaowu, Jinjiang and Shishi city. The surveillance of rodents showed that the mean population density of rodents was 6.83% indoors, and Rattus norvegicus, which carried Soul virus, was the predominant species. In the mixed epidemic area,the mean population density of rodents was 5.60% in the field, and Apodemus agrarius was the predominant species. HV antigen was detected for the first time from R. norvegicus and R. tanezumi in Yunxiao, Qingliu, and Mingxi counties. Conclusion Rattus norvegicus is still the main host animal of HFRS in Fujian. The incidence of HFRS was at the highest level in 2013-2015 in Fujian, especially in Shaowu city, Songxi, Zhenghe, and Zhouning counties. Rodent control should be well performed, and HFRS bivalent vaccine should be widely used among the high-risk populations, so as to reduce the incidence and prevent the outbreak of HFRS.