目的 调查广东省揭阳市一个建筑工地登革热暴发疫情的流行病学特征及评价疫情处置效果。方法 采用现场流行病学调查方法对病例进行调查分析,于2014年10月9日至11月11日采集患者血液进行抗体检测和核酸检测,应用布雷图指数开展蚊媒密度调查。结果 首例发病为2014年9月26日,末例发病10月12日,流行期16 d,共发病22例,罹患率为14.7%(22/150),采取防控措施后,蚊媒密度明显下降,疫情得到有效控制。登革热病毒进化分析显示工地病例分离株序列与广州市流行株有极高的遗传相似度。结论 该起疫情由登革热1型病毒引起,传染源可能来自广州市,早期病例的误诊是导致疫情在工地内传播的主要原因,政府部门及时应对和防蚊措施有效落实是成功防控登革热的关键。

Objective Investigation of epidemiological characteristics of one dengue outbreak in a construction site in Jieyang city, Guangdong province, and evaluation of response outcome. Methods Investigate all cases in the site by epidemiology survey methods, collect blood samples from the workers for antibody detection and nucleic acid test, and survey the density of mosquito larvae by Breteau index. Results The 22 cases in total happened within 16 d, the first case on 26^th September and the last case on 12^th October with a morbidity of 14.7% (22/150) on this construction site. The mosquito density was decreased after the implement of control measures and the dengue outbreak was effectively contained. The isolates of dengue virus from cases had high similarity with the isolates from Guangzhou cases by Dengue virus phylogenetic analysis. Conclusion The outbreak was caused by dengue virus type 1. The source of infection might have come from Guangzhou. Early cases were not recognized in time due to misdiagnosis which led to the spread of dengue on a construction site. The key point for the successful prevention and control of dengue fever was the timely response of governmental departments and the effective implementation of mosquito control measures.