目的 通过对以往青海地区链霉素治疗鼠疫病例单独和联合使用抗生素疗效的比较和分析,探索合理使用新型抗生素治疗鼠疫病例的新方法。方法 回顾性调查分析以往鼠疫病例,以年龄、病型、链霉素总用量、链霉素治疗时间为指标,对链霉素单独和联合应用治疗鼠疫病例的疗效进行比较和分析。采用SPSS 10.0软件进行有关统计学分析。结果 链霉素单独和联合应用治疗腺鼠疫,在链霉素总用量和治疗时间上有差别,经统计学检验差异有统计学意义;治疗肺鼠疫差异无统计学意义。结论 链霉素与环丙沙星联合应用治疗腺鼠疫时,可以降低链霉素的用量和缩短治疗时间;但治疗肺鼠疫时,链霉素的用量和缩短治疗时间无明显差异。

Objective Through the comparison and analysis of efficacy between streptomycin administered alone or in combination with ciprofloxacin to treat human plague cases in Qinghai province, to seek new solution for bubonic plague cases. Methods Plague cases were retrospectively analyzed by gathering case data such as age, disease type, the amount of streptomycin, streptomycin treatment time as targets,compared and analyzed the efficacy between streptomycin alone or jointly used treatment for the past human plague cases. SPSS 10.0 was used to do the related statistics analysis. Results Individual and joint application of streptomycin for bubonic plague in terms of amount of streptomycin and treatment time had statistically significant difference. As to the pneumonic plague however, there was significant difference. Conclusion Streptomycin in combination with ciprofloxacin could reduce the amount of streptomycin and treatment time for the bubonic plague, but the treatment's effect on pneumonic plague was not obvious.