目的 探讨复合型鼠类不育剂CQ-1对鸡的安全性。方法 试验设不育剂饵料4个浓度为0、10、15、20 mg/kg,对鸡连续无选择饲喂10 d,给药结束继续观察30 d后解剖所有个体,记录鸡的一般体征、取食量、体重、产蛋率、内脏器官等指标,并与对照组比较,评价复合型鼠类不育剂CQ-1对非靶动物的安全性。结果 不育剂处理下鸡的一般体征无明显异常,对照组的取食量最高为(0.44±0.12)g/kg,3个不育剂处理组取食量均显著低于对照组,鸡平均食入纯药量最高为20 mg/kg的处理达(4.20±1.44)μg/kg。3个处理组鸡的体重有暂时性下降,而对照组鸡的体重持续增长。3个处理组鸡的产蛋率均有下降,15 mg/kg处理组下降幅度最多,达到49.3%,第41～50 天,3个不育剂处理组产蛋率回升均可恢复正常。解剖检查脏器,3个不育剂处理组均无明显异常,内脏系数和对照组相比差异无统计学意义。结论 复合型鼠类不育剂CQ-1对鸡毒性较小,最高浓度20 mg/kg连续无选择饲喂10 d不会导致鸡死亡,虽然不育剂会使鸡的体重和产蛋率下降,但均可恢复。

Objective To study the safety of compound sterilant CQ-1 in chickens. Methods Sterilant baits (0, 10, 15, and 20 mg/kg) were used to feed chickens for 10 consecutive days. All test chickens were dissected after 30 days of observation. The indices, such as general signs, food consumption, body weight, egg-laying rate, and organ coefficient, of the sterilant-fed chickens were recorded and compared with those of control group. The safety of compound sterilant CQ-1 for non-target animals was evaluated. Results No obvious abnormity was observed in any of the chickens fed with the sterilant. The control group had a maximum food consumption of 0.44±0.12 g/kg, and the 3 sterilant treatment groups had significantly less food consumption than the control group. The 20 mg/kg treatment group had a pure drug consumption of 4.20±1.44 μg/kg. The 3 sterilant treatment groups had temporary decreases in body weight, while the control group had a sustained increase in body weight. The egg-laying rate decreased in the 3 sterilant treatment groups, most (down 49.3%) in the 15 mg/kg treatment group. On days 41-50, the egg-laying rate rose and returned to normal in the 3 sterilant treatment groups. No abnormal organs were found in the 3 sterilant treatment groups after dissection, and there was no significant difference in organ coefficient between the treatment groups and the control group. Conclusion Compound sterilant CQ-1 has little toxicity to chickens. Chickens do not die after being fed with the sterilant at 20 mg/kg for 10 consecutive days. Although the body weight and egg-laying rate decrease temporarily in sterilant-fed chickens, the two indices can return to normal later.