中国媒介生物学及控制杂志 ›› 2023, Vol. 34 ›› Issue (1): 9-13.DOI: 10.11853/j.issn.1003.8280.2023.01.002

• 实验研究 • 上一篇    下一篇

喜马拉雅旱獭自然感染鼠疫耶尔森菌后部分脏器病理变化的研究

张芃1, 周永运2, 吕东月3, 贺兆锴4, 段然1, 秦帅1, 汤德铭1, 肖萌1, 景怀琦1, 王鑫1   

  1. 1. 中国疾病预防控制中心传染病预防控制所应急实验室, 北京 102206;
    2. 中国合格评定国家认可中心, 北京 100062;
    3. 上海市浦东新区疾病预防控制中心, 上海 200120;
    4. 杭州市疾病预防控制中心, 浙江 杭州 310021
  • 收稿日期:2022-09-13 出版日期:2023-02-20 发布日期:2023-02-16
  • 通讯作者: 王鑫,E-mail:wangxin@icdc.cn
  • 作者简介:张芃,女,在读硕士,主要从事病原生物学研究,E-mail:1064226260@qq.com
  • 基金资助:
    国家科技重大专项(2018ZX10713-001-002)

Pathological changes of some organs of Marmota himalayana naturally infected with Yersinia pestis

Peng ZHANG1, Yong-yun ZHOU2, Dong-yue LYU3, Zhao-kai HE4, Ran DUAN1, Shuai QIN1, De-ming TANG1, Meng XIAO1, Huai-qi JING1, Xin WANG1   

  1. 1. Emergency Response Laboratory, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China;
    2. China National Accreditation Service for Conformity Assessment, Beijing 100062, China;
    3. Shanghai Pudong New Area Center for Disease Control and Prevention, Shanghai 200120, China;
    4. Hangzhou Center for Disease Control and Prevention, Hangzhou, Zhejiang 310021, China
  • Received:2022-09-13 Online:2023-02-20 Published:2023-02-16
  • Supported by:
    National Science and Technology Major Project of China(2018ZX10713-001-002)

摘要: 目的 了解喜马拉雅旱獭(旱獭)自然感染鼠疫耶尔森菌(鼠疫菌)所导致的脾质量和主要脏器的组织病理变化,揭示鼠疫的致病特点。方法 分析2020-2021年获得的活体旱獭及自毙旱獭脾质量与体质量的比值,取正常旱獭以及感染鼠疫菌自毙旱獭的肝、肺、脾脏3种器官制作病理切片,并观察组织病理学变化。结果 感染鼠疫菌的自毙旱獭脾质量与体质量的比值明显高于未感染鼠疫菌的旱獭,且差异有统计学意义(χ2=33.144,P<0.001)。感染鼠疫菌自毙旱獭的肝、肺、脾脏均有细胞形态被破坏,炎性细胞浸润,血管扩张等炎症病变,脾脏的血管损伤和红髓白髓的变化更为明显。结论 鼠疫菌可引起旱獭机体产生严重的炎症反应,脾脏的病变对于探讨鼠疫菌的致病过程和机制更具研究意义。

关键词: 鼠疫, 喜马拉雅旱獭, 病理学

Abstract: Objective To investigate the weight of spleen and the histopathological changes of main organs caused by natural infection of Yersinia pestis in Marmota himalayana (marmot), and to reveal the pathogenic characteristics of plague. Methods The ratio of spleen weight to body weight of living marmots and self-dead marmots obtained from 2020 to 2021 was analyzed. The liver, lung, and spleen of normal marmots and self-dead marmots infected with Y. pestis were collected to make pathological sections for observing histopathological changes. Results The ratio of spleen weight to body weight of self-dead marmots infected with Y. pestis was statistically greater than that of marmots not infected with Y. pestis (χ2=33.144, P<0.001). In the liver, lung, and spleen of self-dead marmots infected with Y. pestis, there were cell morphology destruction, inflammatory cell infiltration, vasodilation, and other inflammatory lesions, and vascular injury of the spleen and changes in the red pulp and white pulp were more significant. Conclusion Y. pestis can cause serious inflammatory reaction in marmots, and the pathological changes of the spleen are of more significance for study of the pathogenic process and mechanism of Y. pestis.

Key words: Plague, Marmota himalayana, Pathology

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