中国媒介生物学及控制杂志 ›› 2017, Vol. 28 ›› Issue (5): 512-514.DOI: 10.11853/j.issn.1003.8280.2017.05.029

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动物鼠疫流行静息期与鼠疫质粒变异关系的探讨

高少坤1, 杜国义2   

  1. 1 蠡县疾病预防控制中心检验科, 河北 保定 071000;
    2 河北省鼠疫防治所, 河北 张家口 075000
  • 收稿日期:2017-05-15 出版日期:2017-10-20 发布日期:2017-10-20
  • 通讯作者: 杜国义,Email:dgyhbs@163.com
  • 作者简介:高少坤,男,副主任医师,从事鼠疫防治工作,Email:530258017@qq.com
  • 基金资助:
    2016年河北省医学重点项目(20170446);国家重点研发计划重点专项(2016YFC1201304)

Study on the relationship between the resting phase of animal plague and the variation of the plague plasmid

GAO Shao-kun1, DU Guo-yi2   

  1. 1 Lixian Center for Disease Control and Prevention, Baoding 071000, Hebei Province, China;
    2 Anti-plague Institute of Hebei Province
  • Received:2017-05-15 Online:2017-10-20 Published:2017-10-20
  • Supported by:
    Supported by the Key Medical Projects of Hebei Province in 2016(No. 20170446)and National Major Research and Development Plan(No. 2016YFC1201304)

摘要: 10、74、107 kb 3种质粒形成了我国各鼠疫自然疫源地内鼠疫耶尔森菌(鼠疫菌)主要质粒图谱,在国内不同疫源地又陆续发现了不同质粒,有16种不同类型,这些质粒分别具有不同的功能。质粒在自然界中容易自然缺失或丢失而使鼠疫菌性状发生变异,也是每次鼠疫流行末期自然终止流行和鼠疫流行静息期存在的原因之一。该文就鼠疫菌质粒变异对鼠疫流行的影响进行了探讨,以供人们对鼠疫流行规律进行研究。

关键词: 静息期, 鼠疫, 质粒, 变异, 鼠疫耶尔森菌

Abstract: There are three plasmids of 10, 74, 107 kb which are main plasmids of Yersinia pestis in the plague natural foci of China. Different plasmids have been found in China and there are 16 different types. Plasmid in nature is easy to be lost and Y. pestis is therefore altered. This is also the cause of natural death at the end of plague and circulating of the plague. Plasmid variation of the Y. pestis is discussed for the plague epidemic. The study of the law of epidemic plague is useful for public health.

Key words: Resting phase, Plague, Plasmid, Variation, Yersinia pestis

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