中国媒介生物学及控制杂志 ›› 2017, Vol. 28 ›› Issue (5): 490-491.DOI: 10.11853/j.issn.1003.8280.2017.05.022

• 调查研究 • 上一篇    下一篇

北京市密云区关节炎患者莱姆病血清学调查

杨育松1, 吕燕宁2, 陈永亮1   

  1. 1 北京市密云区疾病预防控制中心, 北京 101500;
    2 北京市疾病预防控制中心, 北京 100013
  • 收稿日期:2017-06-29 出版日期:2017-10-20 发布日期:2017-10-20
  • 作者简介:杨育松,男,副主任技师,主要从事传染病地方病防治工作,Email:yys.715@163.com

Serological investigation in arthritis patients with Lyme disease in Miyun district, Beijing

YANG Yu-song1, LYU Yan-ning2, CHEN Yong-liang1   

  1. 1 Miyun District Center for Disease Control and Prevention, Beijing 101500, China;
    2 Beijing Center for Disease Control and Prevention
  • Received:2017-06-29 Online:2017-10-20 Published:2017-10-20

摘要: 目的 了解北京市密云区关节炎患者伯氏疏螺旋体感染状况,为莱姆病防治工作提供科学依据。方法 2016年在密云区采集关节炎患者血清标本,采用ELISA法对血清标本进行莱姆病抗体初筛检测,阳性血清标本采用免疫印迹法进行确证。结果 共采集关节炎患者血清标本140份,莱姆病抗体阳性17份,总抗体阳性率为12.14%;莱姆病IgM抗体和IgG抗体阳性率分别为2.86%(4/140)和9.29%(13/140)。总抗体阳性率女性高于男性,50~岁年龄组总抗体阳性率最高,不同乡镇人群差异无统计学意义(χ2=10.385,P=0.320);临床以膝关节病变患者最多。结论 密云区存在伯氏疏螺旋体感染导致的关节炎症状患者,因此临床医生在诊治关节炎患者时,应考虑莱姆病的鉴别诊断。

关键词: 莱姆病, 血清标本, 抗体检测, 关节炎

Abstract: Objective To investigate the infection status in arthritis patients with Lyme disease in Miyun district, and to provide scientific basis for the prevention and treatment of Lyme disease. Methods Serum samples of patients with arthritis were collected, Lyme disease antibody screening in serum samples were detected by enzyme-linked immunosorbent assay, and positive serum samples were identified by western blot. Results A total of 140 serum samples were collected, 17 samples were positive of Lyme disease antibody, the total positive rate was 12.14%. Four serum samples were positive for Lyme disease IgM antibody, the positive rate was 2.86%, 13 serum samples were positive for Lyme disease IgG antibody, the positive rate was 9.29%. The total positive rate of antibody was higher in women than men, and the total positive rate of antibody was highest in 50- years old age group, there were no significant differences in total positive rate between different districts. Conclusion There were patients with arthritis caused by the Borrelia burgdorferi infection in Miyun district, so clinicians should consider Lyme disease in the diagnosis and treatment of arthritis patients.

Key words: Lyme disease, Serum samples, Antibody detection, Arthritis

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