应用沃尔巴克氏体通过种群替换阻断蚊媒病的传播

doi:10.11853/j.issn.1003.4692.2015.01.003

中国媒介生物学及控制杂志 ›› 2015, Vol. 26 ›› Issue (1): 11-15.DOI: 10.11853/j.issn.1003.4692.2015.01.003

应用沃尔巴克氏体通过种群替换阻断蚊媒病的传播

李永军¹, 刘起勇^2,3, 奚志勇^1,4

1. 中山大学-密歇根州立大学热带病虫媒控制联合研究中心, 广东广州510080;
2. 中国疾病预防控制中心传染病预防控制所, 传染病预防控制国家重点实验室;
3. 世界卫生组织媒介生物监测与管理合作中心;
4. 美国密歇根州立大学微生物学和分子遗传学系

收稿日期:2014-09-18 出版日期:2015-02-20 发布日期:2015-02-20
作者简介:李永军,男,博士,从事感染沃尔巴克氏体的蚊虫宿主的媒介效能研究,Email: liyongjun_sysu@126.com
基金资助:
教育部科学技术研究重点(重大)项目(311030);广东省引进创新科研团队计划(2011S009);广州市开发区科技领军人才项目(2013L-P116);美国国立卫生研究院和盖茨全球健康大挑战联合基金;美国国立卫生研究院/国家过敏症与传染病研究所基金(R01 AI-080597);国际原子能地区合作项目(RAS5066)

Blocking the transmission of mosquito-borne diseases through Wolbachia-based population replacement

LI Yong-jun¹, LIU Qi-yong^2,3, XI Zhi-yong^1,4

1. Sun Yat-sen University-Michigan State University Joint Center of Vector Control for Tropical Diseases, Key Laboratory for Tropical Disease Control, Ministry of Education, Guangzhou 510080, Guangdong Province, China;
2. State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention;
3. WHO Collaborating Centre for Vector Surveillance and Management;
4. Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA

Received:2014-09-18 Online:2015-02-20 Published:2015-02-20
Supported by:
Supported by the Key Project of Chinese Ministry of Education(No. 311030), Guangdong Innovative Research Team Program (No. 2011S009), Scientific and Technological Leading Talents of Guangzhou Development District (No. 2013L-P116), a Grant from the Foundation for the NIH Through the Grand Challenges in Global Health Initiative of the Bill, Melinda Gates Foundation, a Grant(No. R01 AI-080597)and from the National Institutes of Health/National Institute for Allergy and Infectious Disease and the IAEA-TC Project(No. RAS5066)

摘要/Abstract

摘要：

由蚊类传播的疾病每年造成人类大量的病例和死亡,然而包括登革热一类的重要蚊媒病至今尚无有效的疫苗用于预防。由于传统的、依赖化学杀虫剂的蚊媒控制方法正面临不断增长的昆虫抗药性和对环境的污染问题,探索对蚊媒的可持续性防治手段正成为目前研究的热点。沃尔巴克氏体可以导致宿主产生胞质不相容现象,并能诱导蚊媒产生对多种人类病原体的抗性,因此基于沃尔巴克氏体的蚊媒种群替换在理论上可以阻断蚊媒病传播。相比于其他生物防治方法,该方法具有低成本、可持续以及环保等特点,已在多个国家开展实地测试,它也是目前最具潜力的蚊媒病生物防治手段之一。

关键词: 沃尔巴克氏体, 蚊媒, 种群替换

Abstract:

Diseases transmitted by mosquitoes result in severe morbidity and mortality every year, and there is an urgent need to develop an effective tool to prevent the most important diseases including dengue and others. Due to rapidly developing resistance in insects and its negative impact on environment, chemical insecticide becomes increasingly difficult to be relied on for disease control. Thus a significant effort is made to develop a sustainable vector control strategy, such as Wolbachia-based vector control. Theoretically Wolbachia-based population replacement would lead to interruption of disease transmission due to the ability of Wolbachia to induce cytoplasmic incompatibility and pathogen interference. Compared with the other control tools, this Wolbachia approach is cost-effective, sustainable and environmental friendly. With field trial currently ongoing in a number of countries, Wolbachia-based vector control is now becoming one of the most promising novel tools for control of mosquito-borne diseases.

Key words: Wolbachia, Mosquito, Population replacement

中图分类号:

R386
R384.1

李永军, 刘起勇, 奚志勇. 应用沃尔巴克氏体通过种群替换阻断蚊媒病的传播[J]. 中国媒介生物学及控制杂志, 2015, 26(1): 11-15.

LI Yong-jun, LIU Qi-yong, XI Zhi-yong. Blocking the transmission of mosquito-borne diseases through Wolbachia-based population replacement[J]. Chines Journal of Vector Biology and Control, 2015, 26(1): 11-15.

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应用沃尔巴克氏体通过种群替换阻断蚊媒病的传播

Blocking the transmission of mosquito-borne diseases through Wolbachia-based population replacement

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