关键词: 肾综合征出血热, 宿主动物, 自然疫源地

Abstract: Objective To investigate the type and range of natural focus of hemorrhagic fever with renal syndrome (HFRS) in Fujian province, China, and to provide a scientific basis for the prevention and control of this disease. Methods An investigation of host animals of HFRS was carried out in 15 surveillance sites between 2009 and 2017. Rodents were captured using cages at night, and the rodent density and constituent ratios were calculated. Immunofluorescent assay was used to detect and identify hantavirus (HV) antigen in rodent lungs. Results The mean rodent density was 7.05% in the 15 surveillance sites, and Rattus norvegicus, which carried Seoul HV, was the dominant species. The mean virus-carrying rate of rodents was 6.27%, and R. norvegicus accounted for 83.78%. The mean virus-carrying index of rodents was 0.07, and Longhai had the highest virus-carrying index of rodents 0.12. HV antigen was detected for the first time from R. norvegicus in the cities or counties of Anxi, Shaxian, Longhai, Zhangpu, Dehua, Wuping, Yunxiao, and Qingliu, and from R. norvegicus and R. tanezumi in the counties of Hua'an, Jiangle, and Mingxi. Conclusion It is confirmed for the first time that there are natural foci of HFRS in the 11 surveillance sites. Rattus norvegicus carrying Seoul HV is the main host animal and source of infection with HFRS. The epidemic area of domestic rodent-type HFRS is spreading to the southern and western areas in Fujian province, and widely distributed.

Key words: Hemorrhagic fever with renal syndrome, Host animal, Natural focus