狂犬病病毒糖蛋白的抗原性和致病性功能研究进展

中国媒介生物学及控制杂志 ›› 2013, Vol. 24 ›› Issue (2): 178-181.

狂犬病病毒糖蛋白的抗原性和致病性功能研究进展

何健^1,2, 张海林²

1 大理学院公共卫生学院,云南大理 671000;
2 云南省地方病防治所/云南省病毒立克次体研究中心,云南大理 671000

收稿日期:2012-10-23 出版日期:2013-04-20 发布日期:2013-04-20
通讯作者: 张海林
基金资助:
国家自然科学基金(30560142)

Progress in functional research on antigenicity and pathogenicity of Rabies virus glycoprotein

HE Jian^1,2, ZHANG Hai-lin²

1 Institute of Public Health, the Dali College, Dali 671000, Yunnan Province, China;
2 Yunan Institute of Endemic Diseases Control and Prevention, Dali 671000, Yunnan Province, China

Received:2012-10-23 Online:2013-04-20 Published:2013-04-20
Supported by:
Supported by the National Natural Science Foundation of China(No. 30560142)

摘要/Abstract

摘要： 狂犬病病毒糖蛋白(GP)的抗原性和致病性研究有助于阐明病毒的免疫应答特点和致病机制,从而为狂犬病的有效防治提供科学依据.GP的抗原性不仅用于各种单克隆抗体、基因工程抗体以及新型疫苗的研究,还可辅助病毒感染的早期诊断和暴露后的早期治疗;而病毒的致病性与GP的表达水平及诱导细胞凋亡的能力有紧密联系.因此,GP的抗原性和致病性已逐渐成为人们的研究热点.该文就狂犬病病毒GP的抗原性和致病性最新研究进展予以综述.

关键词: 狂犬病病毒, 糖蛋白, 抗原性, 致病性, 狂犬病疫苗

Abstract: The study on the antigenicity and pathogenicity of rabies virus (RV) glycoprotein (RVG) is helpful for clarifying the characteristics of immune response to RV and the pathogenesis of rabies, thus providing a scientific basis for effective prevention and treatment of rabies. The antigenicity of RVG is not only utilized in the research on various monoclonal antibodies, genetic engineering antibodies, and new rabies vaccine, but also aids in early diagnosis of RV infection and early treatment after RV exposure. On the other hand, the pathogenicity of RVG is closely related to the expression level of RVG and its ability to induce cell apoptosis. Consequently, the antigenicity and pathogenicity of RVG have gradually become major foci of research. The purpose of this paper is to review the recent progress in the research on the antigenicity and pathogenicity of RVG.

Key words: Rabies virus, Glycoprotein, Antigenicity, Pathogenicity, Rabies vaccine

中图分类号:

R512.99

何健, 张海林. 狂犬病病毒糖蛋白的抗原性和致病性功能研究进展[J]. 中国媒介生物学及控制杂志, 2013, 24(2): 178-181.

HE Jian, ZHANG Hai-lin. Progress in functional research on antigenicity and pathogenicity of Rabies virus glycoprotein[J]. Chines Journal of Vector Biology and Control, 2013, 24(2): 178-181.

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