中国媒介生物学及控制杂志 ›› 2012, Vol. 23 ›› Issue (4): 366-369.

• 综述 • 上一篇    下一篇

蚊虫抗药性分子机制研究进展

刘宏美, 代玉华, 公茂庆   

  1. 山东省医学科学院, 山东省寄生虫病防治研究所, 山东济宁 272033
  • 收稿日期:2012-03-29 出版日期:2012-08-20 发布日期:2012-08-20
  • 通讯作者: 公茂庆,Email: maoqingg@yahoo.com
  • 基金资助:
    山东省国际科技合作项目(LKH09-187-06);山东省自然科学基金(ZR2010HL020);山东省优秀中青年科学家科研奖励基金项目(bs2011SW032)

Advances in the molecular mechanisms of mosquito resistance to insecticides

LIU Hong-mei, DAI Yu-hua, GONG Mao-qing   

  1. Shandong Academy of Medical Sciences, Shandong Institute of Parasitic Diseases, Jining 272033, Shandong Province, China
  • Received:2012-03-29 Online:2012-08-20 Published:2012-08-20
  • Supported by:
    Supported by the International Science and Technological Cooperation Project of Shandong Province(No. LKH09-187-06),the Natural Science Foundation of Shandong Province(No. ZR2010HL020)and Excellent Young Scientist Research Award Projects of Shandong Province(No. bs2011SW032)

摘要: 蚊虫是重要的医学昆虫,可以通过叮咬传播疾病(例如疟疾、丝虫病、登革热等),其行为与人类生活息息相关。由于长久以来大量、广泛地使用杀虫剂,使蚊虫抗性日益严重。蚊虫的抗性机制主要有靶标抗性(包括神经轴突钠离子通道、乙酰胆碱酯酶和γ-氨基丁酸受体氯离子通道的突变)和代谢抗性(包括非特异性羧酸酯酶、细胞色素P450和谷胱甘肽-S-转移酶的活性增加)两方面。现对这些机制的研究进展进行综述,试图全面了解大量、广泛使用杀虫剂之后蚊虫抗性产生的分子机制。

关键词: 蚊虫, 抗药性, 靶标抗性, 代谢抗性

Abstract: Mosquitoes, which act as important medical insects, can transmit diseases such as malaria, fiariasis and dengue fever, etc. by bites, being harmful to humans. For a long period of time, due to the extensive use of chemical insecticides, the insecticide resistance in mosquitoes is becoming more and more serious. The mechanisms of resistance can be classified into two groups, knockdown resistance (such as saltations in sodium channel, Acetylcholinesterase and γ-aminobutyric acid) and metabolic resistance (such as augmentations in carboxylesterase, cytochrome P450 and glutathione-S-transferase). In this article, recent research advances in the resistance of mosquitoes to chemical insecticides are reviewed for better understanding of the molecular mechanism of mosquito resistance to the extensively used chemical insecticides.

Key words: Mosquito, Insecticide resistance, Target site resistance, Metabolic resistance

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