中国媒介生物学及控制杂志

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827例拟诊莱姆病患者抗伯氏疏螺旋体抗体检查结果分析

耿震;侯学霞;郝琴;胡桂兰;万康林   

  1. 中国疾病预防控制中心传染病预防控制所传染病预防控制国家重点实验室 北京 102206
  • 出版日期:2007-06-20 发布日期:2007-06-20

Anti-borrelia burgdorferi antibody response in 827 patients with suspected Lyme disease

GENG Zhen; HOU Xue-xia; HAO Qin; HU Gui-lan; WAN Kang-lin   

  1. National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
  • Online:2007-06-20 Published:2007-06-20

摘要: 目的 分析拟诊莱姆病患者血清学检查结果,明确莱姆病临床病症及地区分布情况,为有效诊治莱姆病提供科学依据。方法 2001-2006年应用间接免疫荧光试验和ELISA 2种方法对来自全国各地的827例临床拟诊莱姆病患者血清进行抗伯氏疏螺旋体IgM、IgG抗体检查。结果 有135例患者血清抗伯氏疏螺旋体IgM、IgG抗体呈阳性反应,阳性率16.32%。其中神经系统疾病344例,阳性88例;心血管系统疾病39例,阳性3例;皮肤病变193例,阳性30例;发热病人102例,阳性6例;关节痛病人105例,阳性5例;精神障碍病人44例,阳性3例。135例患者应用抗生素治疗后有效率达92%。我国18个省(直辖市、自治区)有莱姆病病例发生,以黑龙江、吉林、内蒙古、新疆最多,其次是青海、四川、贵州、云南、浙江等省。结论 我国人群确实存在莱姆病螺旋体散发感染,通过血清学检查能及早发现病人,提高诊疗效率。

关键词: 莱姆病螺旋体, 血清, 间接免疫荧光试验, 酶联免疫吸附试验

Abstract: Objective Analysis the result of blood serum test for suspected Lyme disease patients,to clear the clinical manifestation and distributed situation of Lyme disease,and provides scientific basis for diagnosis and treatment of Lyme disease.Methods With indirect immunofluorescence assay(IFA) and enzyme-linked immunosorbent assay(ELISA),an investigation on antibodies(IgM,IgG) of Borrelia burgdorferi was carried out in sera of 827 suspected Lyme disease patients.Results From 2001 to 2006,we examined 827 suspected Lyme disease patients,135 patients of them were antibody positive(16.32%).The positive constitution ratio of the neurological disorders,cardiovascular system patients,skin disorders and fever patients was 65.18%(88/344),2.22%(3/39),22.22%(30/193),and 4.44%(6/102),respectively.Five specimens of 105 patients with arthritis was positive.Among the forty-four psychiatric derangements,three specimens was positive.Ninety-two percent of the total 135 positive patients had good curative effects after the treatment of antibiotic.There are Lyme disease in eighteen provinces,metropolises and autonomous regions in China.There are more confirm cases in Heilongjiang,Jilin,Neimenggu,Xinjiang than Qinghai,Sichuan,Guizhou,Yunnan,Zhejiang and so on.Conclusion There are lots of sporadic cases of Lyme disease in China,we can find out these patients early by blood serum test,and improved the efficient of diagnosis and treatment.