中国媒介生物学及控制杂志

• 论著 • 上一篇    下一篇

浙江省肾综合征出血热监测研究

傅桂明1;龚震宇1;赵芝雅1;崔清荣2;高弈3;曹品元4;朱匡纪5;毛立雄6;庞卫龙2;方春福7;刘令初8;朱智勇1   

  1. 1浙江省疾病预防控制中心消毒杀虫所 杭州310009;2天台县疾病预防控制中心;3开化县疾病预防控制中心;4宁海县疾病预防控制中心;5金华婺城区疾病预防控制中心;6江山市疾病预防控制中心;7衢州市疾病预防控制中心;8台州市疾病预防控制中心
  • 出版日期:2005-12-20 发布日期:2005-12-20

Epidemiological Surveillance on Hemorrhagic Fever with Renal Syndrome in Zhejiang Province

FU Gui-ming;GONG Zhen-yu;ZHAO Zhi-ya;et al   

  1. Center for Disease Control and Prevention of Zhejiang Province,Hangzhou 310009,China
  • Online:2005-12-20 Published:2005-12-20

摘要: 目的 掌握浙江省肾综合征出血热(HFRS)人间和动物间疫情动态变化,为制定防制对策提供依据。方法 选择监测点分析人间疫情,开展宿主动物调查,测定鼠密度和带病毒率,采集病人血清进行分型鉴定。结果 1984~2001年天台县、开化县、江山市、宁海县及金华婺城区5个监测点共发生HFRS病人12027例,死亡86例,年平均发病率为35.52/10万,死亡率为0.25/10万,病死率为0.72%。以20世纪80年代发病较高,1986年达到高峰,发病率达119.84/10万。开化县发病率最高,年平均79.03/10万。每年11月至次年1月为流行高峰,占病例总数的44.55%(5334/11974),4~6月为流行小高峰,占20.57%(2463/11974),季节分布呈双峰型。年龄分布以青壮年为主,其中26~45岁人群发病4818例,占病例总数(9715例)的49.59%;男女之比为1.71∶1;农民占发病总数的86.25%。室内、外平均鼠密度为9.98%(34411/344741)。其中室外鼠密度为10.84%(19839/183003),居民区为9.01%(14572/161738)。开化县鼠密度最高,达到14.47%(4521/31249)。室内以褐家鼠为优势鼠种,占75.87%,其次为小家鼠;野外以黑线姬鼠为优势鼠种,占74.44%,其次为黄毛鼠。黑线姬鼠带病毒率为5.21%(598/11477),褐家鼠带病毒率为4.18%(375/8979)。临床确诊病人的血清阳性率为67.81%(4008/5911),恢复期血清分型鉴定,姬鼠(Ⅰ)型病人占60.91%(296/486),家鼠(Ⅱ)型病人占32.51%(158/486),另有6.58%(32/486)的病人未分型。健康人群隐性感染率为3.58%。结论 浙江省属以姬鼠型为主的混合型HFRS疫区,鼠密度和带病毒率仍然较高,需要加强监测和防制。

关键词: 肾综合征出血热, 监测, 发病率

Abstract: Objective To study the epidemiological charactristics of Hemorrhagic fever with renal syndrome(HFRS) in Zhejiang province for preventive measures against the disease. Methods Animal hosts were investigated in surveillance area during 1984-2001.The serum of the patients were collected to test. Analysis both the rodents density and rodents virus carried rate. Results 12 027cases were reported in five surveillance areas of Zhejiang Province with an annual incidence of 35.52/100,000. 86 patients died with a fatality rate of 0.72%. HFRS was primarily a diease of the youth male peasants. Most infections happened in November to next January and April to June. The average density of rodents is 10%. The serum positive rate of patients is 67.81%. Apodemus mode( 60.91%) is the main type. Conclusion Zhejiang Province belonges to mixed epidemic area of HFRS and the Apodemus mode is primary.