关键词: 登革病毒, 实验小鼠, 实验感染

Abstract: Objective:To understand the mechanisms of Den-2 virus infection on Balb/C laboratory mice.Methods:The laboratory mice were injected intravenously in its abdoman with a defined titers of Den-2 virus.Results:It showed Balb/C laboratory mice could be infected with Den-2 virus,although it was not the susceptible host of dengue virus.It can develop a 1-2 days detectable viremia,Den-2 antibody can be detected in the 4^thday after injected.In the first two days,the infection rates of macrophages in abdomical cavity were high,but dropped rapidly.4 days later,the rates were very low.Conclusion:Balb/C laboratory mice can be used for study on the animal model infected with Den-2 virus.