关键词: 肾综合征出血热, 监测, 疫区类型, 血清学分型

Abstract: Objective:To study the types of the epidemic area of Haemorrhage Fever with Renal Syndrome(HFRS),to provide the evidence for HFRS control.Method:With the methods of descriptive epidemiology,seroepidemiology,molecular biology and statistics.Results:The epidemic areas of HFRS in Henan province includes 3 types,Rattus-type area(R area),Apodemus-type area(Aarea) and mixed-type area(Marea).This was defined on the bases of the epidemic feature,clinical manifestation and the major Hantavirus-carrying rodent kinds.Epidemiologic surveillance was carried out in the three types of areas.1.In the last decade,HFRS incidence of Apodemus-type area tended to decline steadily,and that of Rattus-type area showed periodical fluctuation.But the incidence of mixed-type area kept a steady tendency.2.In Apodemus -type areas,HFRS cases happened mainly between October and January of the next year,therefore formed a seasonal peak.In Rattus-type areas,the peak appeared between April and June,while in mixed-type areas,there were both two peaks.3.By rodent constitution investigation and hantavirus antigen detection,it was found that the dominant kinds of murine in residential and field areas were similar among three types of epidemic areas.But the major hantavirus-carrying kinds were different.4.Investigation using serology and molecular biology methods demonstrated that the Seoul virus existed in some places of Apodemus-type areas.It shows that some Apodemus -type areas have been evolving into mixed type areas.Conclusions:Different epidemic features menifest in different types of epidemic areas,so that different precautionary measures should be taken according to surveillance data.Furthermore,special attention should be payed to epidemic type evolving.