中国媒介生物学及控制杂志

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子午沙鼠感染戊肝病毒传代的实验研究

赵素元1;廖立夫2;邹林樾1;于志红1   

  1. 1新疆自治区人民医院肝炎室 乌鲁木齐830001;2新疆自治区地方病防治研究所动物室
  • 出版日期:2001-06-20 发布日期:2001-06-20

Study of Experiment on HEV Infection in Gerbil Meriones meridianus)from Generation to Generation

ZHAO Su-yuan*; LIAO Li-fu; ZOU Lin-yue; et al   

  1. Depatment of Hepatitis.People's General Hospital of Xinjiang Autonomous Region, Urumqi Xinjiang 830001
  • Online:2001-06-20 Published:2001-06-20

摘要: 目的:子午沙鼠实验感染HEV的传代研究。方法:选健康子午沙鼠腹腔接种含HEV的人粪便悬液,接种后观察43~50d,分别记录临床表现、酶血症和排毒结果、肝组织学改变。第1代7只,第2、3代各20只,依次进行逐代感染,连续3代。结果:临床表现不明显,酶血症反应3代基本一致,第6d开始,50d渐复常,呈双峰型;肝组织学改变:经光镜和电镜检查显示,与人戊肝病理改变相似。结论:实验证实子午沙鼠可连传3代,有与人类戊肝相似的特征,具动物模型的条件。

关键词: 子午沙鼠, 戊肝病毒(HEV), 传代

Abstract: Objective:Test of HEV infection in Meriones meridianus step by step in generation.Method:The suspention liquid of waste of man,who was HEV patient,were injected into the abdominal cavities of healthy M.meridianus which were observed in 43-0 days afte injected.It was recorded for the clinical characters,Blood-enzyme,results of wasting HEVRNA,and the changes of liver's histology.The 7 bodies in the first time and 20 bodies both the second and third were injected step by step in generation respectively.Result:There were indistictively clinical characters,and similar reactions of blood-enzyme in all generations.There were two peak models of blood-enzyme from the 6 day to the 50 day after injectsd.Comparison of changes in liver histology was similar between the gerbils infected by HEV and the HEV patients.Conclusion:The experiments shown that gerbil can be infected by HEV step by step in three generations,in which the clinical characters is similar to HEV patients,and considered as laboratory animal model for HEV.