关键词: 肾综合征出血热, 自然疫源地, 血清流行病学调查

Abstract: Objective:To identify if natural epidemic areas of Hemorrhagic Fever with Renal Syndrome(i.e.Epidemic Hemorrhagic Fever,EHF)exit in Linzhi areas of Tibet.Method:Human epidemic situation investigations were selected in reported areas of HFRS;Specific antibodies were detected of health population;The number of small animals were studied in forest region,in plain farms and residential areas;Hantan virus(HV) infection were detected of blood and lung samples in captured animals and blood samples of cattle and sheep,antigens of Hantan virus were detected in lung slice with Immune Fluorescence(IF);Antibodies of HV were detected in blood samples with gold standard immune blot and indirect-IF.Results:1 case of HFRS was reported in Gongbujiangda county in 1976,9 cases in Linzhi county in 1980;18 hospitalized patients,357 high school students and other 117 physical detected persons were examined,only 2 students of Linzhi county,2 students of Gongbujiangda,1 student of Chayu county and 1 maternity were identified positive of HV antibody and antibody IgG,the recessive infection rate was 1.22%;1 positive of 115 detected Apodemus draco,the virus carrying rate was 0.87%;5 Apodemus draco,1 Apodemus draco positive of total antibody and IgG,positive rate of antibody was 5.22%.The positive rate of total antibodies and IgG in cattle against HV was 0.85%(1/118) and sheep against HV was1.68%(3/179) of all 310 detected blood samples.Conclusion:The fact that rare cases existed in Linzhi area of Tibet,HV infection occurred in health population,Apodemus draco and Alticola argentayus.There existed the HFRS natural epidemic areas in forest and plain farms of Linzhi areas.