关键词: 抗凝血剂, 凝血酶原时间, 半数致死量, 1／2半数致死量

Abstract: The paper reported the prothrombin time determition for Rattus norvegicus and mice to three kinds of anticoagulant rodenticides(Bromadiolone;Coumatetralyl;DiphacinonNa). In 24h the time of prothrombin of R.norvegicus was extended obviously with LD₅₀ and half LD₅₀.The time of prothrombin of most R.norvegicus passed 200's and some body died in 48h.In 120h most of them died. For mice,the prothrombin time was extended slightly in 24h with LD₅₀ and half　LD₅₀.In 48h the time of prothrombin return to normal in the main. But in 72h it was extended over 200's. most Mice died in 168h.It was showed that three kinds of anticoagulant rodenticides are sensitive to R.norvsgicus and mice.