中国媒介生物学及控制杂志

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C型肉毒梭菌毒素对小白鼠LD(50)测定及现场灭鼠效果观察

李述杨1; 张增炬1; 吴锡进2; 陈小彬3; 詹绍琛1   

  1. 1福建省地方病防治研究所 福州350001; 2尤溪县爱卫会办公室; 3莆田市卫生防疫站
  • 出版日期:1998-02-20 发布日期:1998-02-20

The Mice LD50 Determination and Rodent Control Field Tests with Botulinum Type C

Li Shu-yang*; Zhang Zeng-ju*; Wu Xi-jin; et al   

  1. *Fujian Provincial Health and Anth-epidemic Station,Fuzhou 350001
  • Online:1998-02-20 Published:1998-02-20

摘要: 目的:观察C型肉毒梭菌毒素对小白鼠的LD50及现场灭鼠效果。方法:毒力测定采用定量药液灌胃法;用粉迹法调查鼠密度,计算灭鼠率。结果:该药在25℃、30℃、35℃放置48小时,对小白鼠的LD50分别为0.0891±0.0473、0.1363±0.0597和0.1712±0.0652ml/kg;现场试验,昼最高气温20~25℃,夜最低气温15~18℃,3个试点村的灭鼠率分别为91.08%、89.41%、88.04%。结论:C型肉毒梭菌毒素的毒力甚强,适宜在我国南方地区推广使用。

关键词: C型肉毒梭菌, 毒素, 小白鼠, 半数致死量, 灭鼠

Abstract: The paper reported the Mice LD50 determination and Rodent control field tests with Botulinum Type C.The LD50 were 0.0891±0.0473 ml/kg by 25℃ for 48h; 0.1363±0.0597 ml/kg by 30℃ for 48h;0.1712±0.0652ml/kg by 35℃ for 48h.The Botulinum Type C was powerful for rodent control.In the field tests with rice baits, the killing rate by the Botulinum Type C was 91.08%; 89.41% and 88.04%.It was showed that the Botulinum Type C fit in with the South China.