中国媒介生物学及控制杂志

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江苏省肾综合征出血热单价灭活疫苗中期免疫效果观察

朱凤才1; 吴扬生1; 胡静1; 祖荣强1; 祁洪山2; 汪杰3; 王庆奎4; 刘光中1   

  1. 1江苏省卫生防疫站 南京210009; 2赣榆县卫生防疫站; 3东辛农场卫生防疫站; 4东海县卫生防疫站
  • 出版日期:1997-10-20 发布日期:1997-10-20

The Two Years Period Observation on the Mass with Inactivated Vaccine against HFRS in Jiangsu Province

Zhu Feng-cai; Wu yang-sheng; Hu Jing; et al   

  1. Jiangsu Provincial health and Anti-Epidemic Station nanjing 210009
  • Online:1997-10-20 Published:1997-10-20

摘要: 观察HFRS单价灭活疫苗中期免疫效果。方法:采用IFAT法及MCPENT法检测荧光抗体及中和抗体。结果:3个试区加强接种人数分别为4052、4407和6354人。加强后,Ⅰ型苗荧光抗体阳性率为72.73%,GMT为14.14;中和抗体阳性率为54.55%,GMT为6.67。D型苗荧光抗体阳性率为75.00%,GMT为11.85;中和抗体阳性率为60%,GMT为9.44。加强后1年,Ⅰ型苗年均保护率为65.52%,Ⅱ型苗则为94.24%。同期,Ⅰ型苗荧光抗体阳性率维持在40%,中和抗体维持在35.00%;Ⅱ型苗荧光抗体阳性率降至10.34%,中和抗体维持在53.85%。结论:两型疫苗均有较好的中期防病效果。

关键词: 肾综合征出血热, 灭活疫苗, 血清学效果, 防病效果

Abstract: On the one year after the whole course inoculation by the vaccine against HFRS, the same tyPe vaccine was inoculated by boost of single injection.The number of the fort inoculati0n: the tyPe Ⅰvaccine 4052 in Denghai county, type Ⅱvaccine 4407 in Ganyu county and 6554 in Dengxin faon the two weeks after the hat inoculation, fluorescent antibody positive rate and GMT were 72.73%, 14.14 and 75.00%, 11.85 in the boost persons inoculated by the type Ⅰand type Ⅱvaccine,respectively, neutralizing antithey positive rate and GMT were 54.55%, 6.67 and 60%, 9.44 in the boot persons inoculated by the type Ⅰand type Ⅱ vaccine, respectively.By the one year after the bot inoculation, the protective rate of the type Ⅱ vaccine was 75.00%, by the two years after whole course inoculation, the average protective rate were 65.52% and 94.24% in the mass inoculated by the type Ⅰand the type Ⅱvaccine, respectively.By the one year after the boost inoculation the fluorescent antibcxly POSitive rate were 40.00% and 10.34% in the mass inoculated by the tyPe Ⅰand the type Ⅱvaccine,respectively, the neutralizing antithey positive rate were 35.00% and 53.85% in the mass inoculated by the type Ⅰand the type Ⅱvaccine, respectively.