中国媒介生物学及控制杂志

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小量多次氟乙酰胺中毒临床诊断及法医学鉴定的探讨

王晓峰; 段亚清; 刘光跃; 李宏图; 何少文   

  1. 白求恩医科大学法医教研室 长春130021; 吉林省卫生防疫站
  • 出版日期:1994-08-20 发布日期:1994-08-20

Study on the Clinical Diagnosis and Forensic Identification of Repeatly Small Amount Fluroacetamide Poisoning

Wang Xiao-feng;et al   

  1. Department of Forensic Medicine, Norman Bethune University of Medical Sciences, Changchun,Jilin Prov,130021
  • Online:1994-08-20 Published:1994-08-20

摘要: 笔者对5例临床诊断为"散发性脑炎"的小量多次氟乙酰胺中毒者,做了回顾性探讨和对动物模型的检测。中毒者临床症状、体征和脑组织病理改变与"散发性脑炎"极其相似,故临床上极易误诊,法医学鉴定若不做毒物分析也易误判。临床生化指标测定结果表明,小量多次氟乙酰胺中毒的人和动物血糖明显降低,血乳酸、血氟、血清LDH及尿氟显著增高,这无疑是中毒者的特征性改变,也是二者临床鉴别诊断的要点。

关键词: 氟乙酰胺, 中毒, 散发性脑炎, 小量多次投毒

Abstract: This paper reviewed five cases of repeatly small amount fluroacetamide poisoning which were diagnosed nonspecific encephalitis in clinic and studied experimental animal model.The clinical symptom,sign of poisoning and the pathological change of cerebral cells were very similar to nonspecific encephalitis.So it was easy to misdiagnosed. It also easy to misjudged in forensic identification without poison analysis. Clinical biochemical measuring showed that the blood sugar of patients and rats which was poisoned by fluroacetamide decreased greatly while the blood lactic acid,blood fluoride, serum lactic dehydrogenase and urine fluoride increased considerably.These were the characteristic changes and also the main points of clinical diagnosis and forensic identification.