中国媒介生物学及控制杂志

• 媒介与疾病 媒介与疾病 • 上一篇    下一篇

流行性出血热灭活疫苗人群接种的现场评价研究

赵斌成; 王淑敏; 柳恒英; 宋新平; 庄礼业; 汪美先; 孙长生; 张世忠   

  1. 兰州空军后勤部卫生防疫队 兰州730020; 空军导弹学院卫生处; 第四军医大学
  • 出版日期:1993-04-20 发布日期:1993-04-20

The evaluation on the immunization of inactivated EHF vaccine in the population

Zhao Bincheng;et al   

  1. Sanita-y and antiepidemic team at logisicss Edpartment in Lan Zhou Air force Command.
  • Online:1993-04-20 Published:1993-04-20

摘要: 1992年3~6月,笔者应用上海生研所1991年中试生产的EHF Z10毒株姬鼠型沙鼠肾细胞灭活疫苗,对某军校的1186名学员与战士进行免疫接种,接种率为94.2%。按人次计算,接种反应发生率为0.62%,且反应轻微,无异常反应,安全性好。疫苗中和抗体、HI抗体和IGM抗体阳转率分别为70~30%、37.3%(35.3~38.9%)、40.2%(37.8~43.5%);而安慰剂组均无阳转。不同批次疫苗接种反应发生率与免疫效果差异均无显著性,生产工艺较稳定。0、7、28天或0、30、60天两种程序免疫,效果未见明显差别。

关键词: 流行性出血热灭活疫苗, 人群免疫, 现场效果评价

Abstract: From March to June in 1992, the numbers of 1180 students and soldiers from some millital school have been immunized with Apodemus type strain in Meriones renal cell-inactived vaccine, produced by Shaing hai sero-zacciae institute in 1991. The cozerage of immunization is 93.5 percent, and the reaction rate after vaccination was 0.62 percent. The reaction all belong to mild. There were np abnormal reaction was found. This show that the vaccine have good safity. The neutration antibody against HI-antibody and IgM antibody to transferred to positive rate after vaccination were 70~80 percent and 37.3~40.2 percent respectively, but the consolation agent given for control grup reveal negative. There no obvious diffirences ware found in diffirent patch of prodicts that included in reaction rate and immunization efficacy. The effectiveness of vaccine could be lasting for 30 or 60 days.