关键词: 约氏疟原虫, 小白鼠, 保护免疫力, 氯喹, 约氏疟原虫感染力

Abstract: 24 mice recovered from initiative sporozoite inoculation after administration with cholroquine were challenged again with sporozoites of salivary glands of infected Anopheles stephensi with P. yoelii, one of them was found reinfected with low level of parasitemia. While of 26 mice recovered from initiative blood inoculation after administration of chloroquine three of them were reinfected by challenge with blood inoculation. But after two cycles of inoculation and drug cure no reinfection was detected at all in the two groups challenged again with sporozoites or positive blood respectively. This result indicates that infection of p. yoelii has shown a stronger protective immunity in mice. however, it is still incomplete. When P. yoelii gametocyte-carrying mice were fed to batches of A. stephensi, 5 of is mice showed infectivity 10 to 20 hours later after administring chloroquine (6mg base/18～20g), and at 20 to 24 hours later after administration of chloroquine the mice were found more less infective to A. stephensi.