中国媒介生物学及控制杂志

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八氯二丙醚及其蚊香烟雾的毒理学研究

唐萌; 林大榕; 谈伟君; 项龙生; 虞秀玢; 高绵伍; 汪国雄; 高锦亚; 龚坤元   

  1. 南京铁道医学院预防医学系 南京210009; 中国科学院动物研究所 南京100080
  • 出版日期:1992-10-20 发布日期:1992-10-20

The study on toxicology of octachlorodipropylether and its mosquito-repellent incense

Tang Meng;et al   

  1. Nanjing Bailway Medical College, Nanjing 210009
  • Online:1992-10-20 Published:1992-10-20

摘要: 本文对八氯二丙醚(S2)原液及其所制蚊香进行毒性毒理学研究。结果表明,S2属低毒物质,致突变试验阴性。S2蚊香亦为低毒物质,但在Ames试验中,TA100-S9的2.0和4.0mg/L两个浓度出现阳性反应;小鼠DNA合成抑制试验,2.73mg/L浓度组对肺和睾丸的DNA合成有影响;蓄积系数K>8,为弱蓄积物质;亚急性毒性试验,各项指标无异常改变。

关键词: 八氯二丙醚, 蚊香烟雾, 毒性, 致突变性

Abstract: Octachlorodipropylether(S2) is a super synergist of synthetic pyrethroid.It has found favour in common people's eyes because of its lower cost and high effectivenes, withoat any tcxicity reported in S2' mosquito-repcllent incense. In order to ensure safety and provide requisite scientific basic for opplication,we have studied S2 and S2' mosquito-repellent about the toxicity and the toxicology. The result shows S2 belongs to lower toxicity substance and mntagenicity test is nagatire.The method of the gaseous state and the inhalation exposure has been taken in toxicity test of S2' mosquito-repllent, and nodrug mosquito-repellent for control. S2' mosquitc-repllentbelongs to lower toxicity substance too,but Ames test showed positive reaction among TA98+S92.0 and 4.0mg/L concentrations, TA100-S9,1.0,2.0,4.0 and 3.0mg/L concentrations, TA100+S9 4.0 and 8.0mg/L concentrations.Assay of mouse DNA synthesis and inhibition, 2.73mg/L concentration group has n influence over DNA synthesis of mouse lungs and testicular cell. Acoumulation coefficient K>8, S2mosquito is part of weak accumulation material,and unusual change is not found in subscute toxicity test.