关键词: 流行性出血热, 灭活疫苗, 中和试验, 血凝抑制试验, 抗体几何平均滴度

Abstract: To observe the efficacy and the epidemiology of inactive HFRS vaccine in large population, a group of 150 people who live collectively in an epidemic area(yearly incidence of 380-860/100,000)were chosen to receive the innoculation, with another group of villigers living around the collective unit treated as control (annual incidences 120-170), of the 150 recipients, 148 show positive neutralizing responeses and 149 of them developed Hemagglutination inhibition specific Abs in their sera, with the average antibody titers of 80.6 and 38.68 respectively. Although Abs in 30 eases dissappeared one year later when booster injection was given, all 150 persons show a complete positive seroconversion, a higher mean titer(81.85), and much lower negative seroconversion rate (5-8%)after two injections. There have been no new patient of EHF diagnosed in this group since its first immunization in 1989-1991.