关键词: 敌溴灵, 溴甲灵, 鼠类, 杀鼠剂毒力

Abstract: A acute rodenticide of Dixiulin (Desmethylbromethalin)derivated from Bromethalin was synthesized by our Institute in 1986, Chemical name is 2, 4-dinitro-N-(2, 4, 6-tribromophenyl )-6-(trifluoromethyl)benzenamine. The appeaance of compound is a buff, odourless and tasteless crystalline material. It is a stable solid, under normal storage conditions with a melting point of 150～152C. It is soluble in organic solvents and insoluble in water. Dixiulin is highly toxic to rodents, chicken and cats. The values of acute oral LD₅₀ with 95% confidence limits(mg/kg)of Dixiulin against these animals are 0.86(0.77-0.96) for rats (Rattus norvegicus albino Wistar), 1.62 (1.51-1.74) mice (Mus musculus albino.) Shanghai), 1.90 (1.19-3.12) hamsters (Cricetulus barabensis albino Beijing), 0.31(1.24-0.40) ground squirrels (Citelins dauricus), 1.16 (0.86-1.67) shrew (Suncus murinus), 6.70 (5.80-9.00) chicken, 0.84～4.54 cats.Dixiulin is acceptable to rats and mice at a concentration of 0.005-0.01% in bait. It is extremely effective against these two species. In two days no-choice feeding test these animals all were killed. In four days choice feeding test albino rats eompletely were killed, and the mortality of albino mice was 90～95%. When rodents were feeded sublethal doses of Dixiulin, the cumulating poisoning action was sligy. Its coefficient K for albino rats arid mice Were 5.06 and 19.2 respectively in lab.The signs of toxicity of Dixiulin can be-classified into two groups dependind upon closes. In the case of doses which exceed the LD₅₀, the signs of toxicity may occur tremors, convulsions. Prostration with death occurring with in 36 hr. In the case of smaller doses the signs of toxicity become a kind leg weakness due to less of muscles tone, paralysis and lethargic. Death may result from respiratory failure.Three field trials against Norway rat (Ruttus norvegicus)and house mouse (Mus musculus) were carried out with 0.005%, 0.01% and 0.015% Dixiulin baits. The population decline ware 91.25% 88.87% and 82.98% respectively. In grassland field trials against ground squirrel (Citillus dauricus) with 0.005%, 0.01% and 0.02% wheat baits, the population decline were 52.30%. 83.20% and 90.00% respectively with in 15 days.