中国媒介生物学及控制杂志 ›› 2022, Vol. 33 ›› Issue (5): 760-764.DOI: 10.11853/j.issn.1003.8280.2022.05.027

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鼠传疾病相关疫苗研究进展

冯群岭1, 刘敏2, 白英1, 黄亚楠1, 李颜1, 王丹1, 史文龙1, 王思奇1, 司海瑞2, 王红红2   

  1. 1. 中国人民解放军 63750部队医院疾病预防控制科, 陕西西安 710043;
    2. 中国人民解放军 63750部队医院, 陕西 西安 710043
  • 收稿日期:2022-05-19 出版日期:2022-10-20 发布日期:2022-10-14
  • 作者简介:冯群岭,男,硕士,副主任医师,主要从事传染病防控研究,E-mail:397068818@qq.com
  • 基金资助:
    军队后勤科研项目(CZZ19J017,145AHQ080005005X)

Advances in research on vaccines for rodent-borne diseases

FENG Qun-ling1, LIU Min2, BAI Ying1, HUANG Ya-nan1, LI Yan1, WANG Dan1, SHI Wen-long1, WANG Si-qi1, SI Hai-rui2, WANG Hong-hong2   

  1. 1. Department of Disease Control and Prevention, PLA 63750 Military Hospital, Xi'an, Shaanxi 710043, China;
    2. PLA 63750 Military Hospital, Xi'an, Shaanxi 710043, China
  • Received:2022-05-19 Online:2022-10-20 Published:2022-10-14
  • Supported by:
    Military Logistics Scientific Research Project (No.CZZ19J017,145AHQ080005005X)

摘要: 鼠传疾病大多是人兽共患的自然疫源性疾病。啮齿动物因种类多、分布广、繁殖能力强而危害严重,随着城市化进程加快、啮齿动物栖息地破坏、人类与啮齿动物接触可能性增加等,多种鼠传疾病的流行区域不断扩大,对鼠传疾病的防治带来严峻的考验和挑战。疫苗接种是最有效的预防和控制疾病的手段,相关疫苗的研发生产大大缓解了国家医疗卫生系统的压力。当前鼠传疾病相关疫苗包括传统疫苗(灭活疫苗、减毒活疫苗)和新型疫苗(基因工程疫苗)。该文系统概述了鼠传疾病疫苗研发的主要进展和未来展望。

关键词: 鼠传疾病, 啮齿动物, 疫苗

Abstract: Most rodent-borne diseases are naturally occurring zoonotic infections.Rodents pose a serious threat due to their diverse species,wide distribution,and strong reproductive ability.With accelerating urbanization,expanding rodent habitat destruction,and increasing human-rodent contact,the epidemic areas of many rodent-borne diseases are enlarging,which poses greatly challenges to the prevention and control of rodent-borne diseases.Vaccination is the most effective means of disease prevention and control.The development and production of vaccines has greatly eased the pressure on the national health care system.Current vaccines for rodent-borne diseases include traditional (inactivated and live attenuated vaccines) and new (genetically engineered vaccines) types.This paper systematically summarized the progress and future prospects of vaccine development for rodent-borne diseases.

Key words: Rodent-borne disease, Rodent, Vaccine

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