中国媒介生物学及控制杂志 ›› 2019, Vol. 30 ›› Issue (5): 589-592.DOI: 10.11853/j.issn.1003.8280.2019.05.027

• 综述 • 上一篇    下一篇

细胞色素P450介导的蚊虫抗药性研究进展

王洋1,2, 宋晓1,2, 程鹏2, 公茂庆2   

  1. 1 济南大学, 山东省医学科学院医学与生命科学学院, 山东 济南 250062;
    2 山东省寄生虫病防治研究所, 山东第一医科大学(山东省医学科学院), 山东 济宁 272033
  • 收稿日期:2019-04-18 出版日期:2019-10-20 发布日期:2019-10-20
  • 通讯作者: 公茂庆,Email:gmq2005@163.com
  • 作者简介:王洋,男,在读硕士,主要从事媒介昆虫抗药性治理与监测工作,Email:wyyang1221@163.com
  • 基金资助:
    国家自然科学基金(81672059,81871685);山东省重点研发计划(2018GSF118040,2019GSF111006);山东省医学科学院医药卫生科技创新工程

Research advances in mosquito resistance to insecticides mediated by cytochrome P450

WANG Yang1,2, SONG Xiao1,2, CHENG Peng2, GONG Mao-qing2   

  1. 1 School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250062, Shandong Province, China;
    2 Shandong Institute of Parasitic Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences
  • Received:2019-04-18 Online:2019-10-20 Published:2019-10-20
  • Supported by:
    Supported by the National Natural Science Foundation of China (No. 81672059, 81871685), Shandong Province Key Research and Development Projects (No. 2018GSF118040, 2019GSF111006) and the Innovation Project of Shandong Academy of Medical Sciences

摘要: 细胞色素P450是一类广泛分布于生物体内的重要酶系,能够代谢多种内源性和外源性物质,在昆虫对杀虫剂代谢解毒方面起着重要作用。P450介导的杀虫剂代谢解毒作用具有普遍性和交互抗性的特点,其机制涉及酶表达量增加和酶活性改变。该文以蚊虫为例综述了P450介导的抗药性一些新进展。

关键词: 蚊虫, 细胞色素P450, 抗药性, 分子机制

Abstract: Cytochrome P450 is an important family of enzymes ubiquitously expressed in organisms. It can metabolize a variety of endogenous and exogenous substances, and plays an important role in the metabolism and detoxification of insecticides in insects. The metabolism and detoxification of insecticides mediated by P450 are characterized by universality and cross resistance, and the mechanisms involve an increase in enzyme expression and a change in enzyme activity. This article reviews some new research advances in the P450-mediated insecticide resistance of mosquitoes.

Key words: Mosquitoes, Cytochrome P450, Insecticide resistance, Molecular mechanism

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