中国媒介生物学及控制杂志 ›› 2018, Vol. 29 ›› Issue (6): 657-661.DOI: 10.11853/j.issn.1003.8280.2018.06.029

• 综述 • 上一篇    下一篇

病媒昆虫的抗药性分子机制研究进展

宋晓, 史琦琪, 程鹏, 公茂庆   

  1. 山东省医学科学院, 山东省寄生虫病防治研究所医学昆虫学部, 山东 济宁 272033
  • 收稿日期:2018-07-31 出版日期:2018-12-20 发布日期:2018-12-20
  • 通讯作者: 公茂庆,Email:maoqingg@yahoo.com
  • 作者简介:宋晓,女,在读硕士,主要从事媒介昆虫抗药性治理与监测工作,Email:15020777096@163.com
  • 基金资助:
    国家自然科学基金(81471985,81672059,81702034);山东省医学科学院医药卫生科技创新工程

Research progress in molecular mechanisms of vector insect's resistance to insecticides

SONG Xiao, SHI Qi-qi, CHENG Peng, GONG Mao-qing   

  1. Shandong Academy of Medical Sciences, Shandong Institute of Parasitic Diseases, Jining 272033, Shandong Province, China
  • Received:2018-07-31 Online:2018-12-20 Published:2018-12-20
  • Supported by:
    Supported by the National Natural Science Foundation of China (No. 81471985, 81672059, 81702034), and the Innovation Project of Shandong Academy of Medical Sciences

摘要: 昆虫抗药性机制的研究对病媒昆虫治理、抗药性监测及新型杀虫剂研发意义重大。近年来,随着昆虫基因组学、蛋白质组学、遗传学与分子生物学的应用,昆虫抗药性机制的研究已取得突破性进展,人们对昆虫的生理代谢、杀虫剂作用靶标、抗性行为等有了更深入的理解。研究表明,昆虫抗药性主要与解毒代谢增强、靶标敏感性降低有关,其本质源于基因变化,包括基因异常扩增、基因结构突变及表达水平改变等。该文对病媒昆虫抗药性机制的研究进行了分子水平的综述。

关键词: 病媒昆虫, 抗药性, 靶标抗性, 代谢抗性, 基因

Abstract: Studies on the mechanisms of insect's resistance to insecticides are extremely significant to the management of vector insects, the monitoring of insecticide resistance, as well as the development of new insecticides. The research of insect's resistance mechanisms has made a breakthrough, recently, with the application of insect genomics, proteomics, genetics and molecular biology, there is a deeper understanding of physiological metabolism, resistance behavior, target-site and the relationship between structure and function of insects. It has been confirmed that insect's resistance is mainly related to enhanced detoxification metabolism and decreased target sensitivity, it rooted from genetic changes, including gene amplification, structure mutation and expression up-and down-regulation. This paper reviewed the progress of vector insect's resistance to insecticidesat the molecular level.

Key words: Vector insects, Insecticide resistance, Metabolic resistance, Target-site resistance, Gene

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