中国媒介生物学及控制杂志 ›› 2018, Vol. 29 ›› Issue (1): 100-102.DOI: 10.11853/j.issn.1003.8280.2018.01.027

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河北省鼠疫自然疫源地鼠疫耶尔森菌变异性研究进展

史献明1, 杜国义1, 王治宇1, 杨顺林1, 王海峰1, 周松1, 刘冠纯1, 谢树军2, 姚剑坤3, 崔树学4, 杨建明5, 张懿晖1   

  1. 1 河北省鼠疫防治所, 河北 张家口 075000;
    2 河北省蠡县医院, 河北 保定 071400;
    3 沽源县疾病预防控制中心, 河北 张家口 075000;
    4 丰宁县疾病预防控制中心, 河北 承德 067000;
    5 康保县疾病预防控制中心, 河北 张家口 075000
  • 收稿日期:2017-10-18 出版日期:2018-02-20 发布日期:2018-02-20
  • 通讯作者: 杜国义,Email:dgyhbs@163.com
  • 作者简介:史献明,男,主任医师,从事鼠疫防治工作,Email:shiwolf@163.com
  • 基金资助:
    2017年河北省医学重点项目(20170446);国家重点研发计划重点专项(2016YFC1201304)

Study on variability of Yersinia pestis in plague natural foci of Hebei province, China

SHI Xian-ming1, DU Guo-yi1, WANG Zhi-yu1, YANG Shun-lin1, WANG Hai-feng1, ZHOU Song1, LIU Guan-chun1, XIE Shu-jun2, YAO Jian-kun3, CUI Shu-xue4, YANG Jian-ming5, ZHANG Yi-hui1   

  1. 1 Anti-plague Institute of Hebei Province, Zhangjiakou 075000, Hebei Province, China;
    2 Lixian County Hospital of Hebei Province;
    3 Guyuan Center of Disease Control and Prevention;
    4 Fengning Center of Disease Control and Prevention;
    5 Kangbao Center of Disease Control and Prevention
  • Received:2017-10-18 Online:2018-02-20 Published:2018-02-20
  • Supported by:
    Supported by the Key Medical Projects of Hebei Province in 2017 (No. 20170446) and the National Major Research and Development Plan (No. 2016YFC1201304)

摘要: 在河北省鼠疫自然疫源地流行初期分离的鼠疫耶尔森菌(鼠疫菌)毒力较强,脱氮能力稳定,质粒种类丰富,但在流行末期分离的鼠疫菌往往毒力较弱,脱氮能力不稳定,质粒易缺失。鼠疫菌的形态学在自然界中存在较大差异。该文通过探讨河北省鼠疫菌的生物学、生化、质粒和毒力变异情况,揭示鼠疫静息期存在的机制。

关键词: 鼠疫耶尔森菌, 变异性, 河北省

Abstract: At the initial stage of epidemics, the bacteria of plague natural foci were more virulent, nitrogen removal was stable, and the plasmid species were relatively complete and stable. But at the end of the epidemic, the virulence of the plague was weaker, nitrogen removal was not stable, and plasmids tended to be absent. There were great differences in the morphology of plague bacteria in nature. Biological, biochemical, plasmid and virulence of Yersinia pestis were investigated in Hebei province, China. The mechanism of the existence of plague was revealed in some way.

Key words: Yersinia pestis, Variability, Hebei province

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