中国媒介生物学及控制杂志 ›› 2015, Vol. 26 ›› Issue (2): 172-175.DOI: 10.11853/j.issn.1003.4692.2015.02.016

• 调查研究 • 上一篇    下一篇

一起经接触传播的发热伴血小板减少综合征疫情调查

黄文忠1, 余向华2, 吴红照1, 张磊3, 缪梓萍3, 吕华坤3   

  1. 1 浦江县疾病预防控制中心, 浙江浦江322200;
    2 温州市疾病预防控制中心;
    3 浙江省疾病预防控制中心, 杭州310051
  • 收稿日期:2014-10-21 出版日期:2015-04-20 发布日期:2015-04-20
  • 通讯作者: 吕华坤,Email:hklv@cdc.zj.cn
  • 作者简介:黄文忠,男,副主任医师,从事传染病控制和流行病学工作,Email:pjhwz8@sina.com
  • 基金资助:

    浙江省公益技术应用基金(2012C33063);浙江省医药卫生平台计划(2014RCA002)

Investigation and analysis on the transmission of severe fever with thrombocytopenia syndrome via contact with patient

HUANG Wen-zhong1, YU Xiang-hua2, WU Hong-zhao1, ZHANG Lei3, MIAO Zi-ping3, LYU Hua-kun3   

  1. 1 Pujiang Center for Disease Control and Prevention, Pujiang 322200, Zhejiang Province, China;
    2 Wenzhou Center for Disease Control and Prevention;
    3 Zhejiang Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang Province, China
  • Received:2014-10-21 Online:2015-04-20 Published:2015-04-20
  • Supported by:

    Supported by the Zhejiang Province Public Technology Application of Fund(No. 2012C33063)and the Medical Research Program of Zhejiang Province(No. 2014RCA002)

摘要:

目的 调查发热伴血小板减少综合征(SFTS)病例的感染来源, 为疫情控制提供科学依据。方法 调查2例患者临床特征和流行病学史, 并对其居家周围的宿主动物(鼠、羊、犬)和蜱进行监测, 对采集到的鼠形动物肝、脾标本和蜱用荧光定量PCR检测发热伴血小板减少综合征布尼亚病毒(SFTSV)特异核酸, 对采集到的鼠形动物血清和羊血清用ELISA方法检测SFTSV抗体。结果 根据临床表现和病原学检测结果病例乙可以确诊为SFTS新发病例, 流行病学调查结果显示该病例无蜱接触史, 很可能是在护理期间接触病例甲的分泌物被感染;患者同村居民的血清学调查结果显示该村存在既往感染或隐性感染, 而且该村家畜和野生动物(鼠)携带蜱, 提示该村可能存在SFTSV的疫源地。结论 SFTS可以经接触传播, 密切接触者应加强个体防护。

关键词: 发热伴血小板减少综合征, 新布尼亚病毒, 接触

Abstract:

Objective To investigate the infection source of severe fever with thrombocytopenia syndrome (SFTS) cases and provide the scientific information for control and prevention of SFTS. Methods The clinical and epidemiological history for 2 cases was investigated and the host animals (rat, sheep, dog) and tick were monitored. The rodent liver and spleen specimens and ticks were detected by fluorescence quantitative PCR, and the rat shape animal serum and goat serum antibody was detected by ELISA. Results Case B was diagnosed as mild case based on clinical symptom and pathogen detection results. Epidemiological investigation showed that case A had no tick exposure history, probably infected during the nursing period. Serological investigation of the results showed that the village had previous or recessive infection. And the domestic and wild animal (rat) in this village carried ticks. All the results hint that this village was novel bunyavirus natural focus. Conclusion Severe fever with thrombocytopenia syndrome can spread through contact. Close contact patients should strengthen individual protection.

Key words: Severe fever with thrombocytopenia syndrome, Novel bunyavirus, Contact

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